Constitutive expression of NF-κB and activated AKT expression have been observed in melanoma and have been suggested to contribute to increased survival of cancer cells, as well as resistance to chemotherapy[70]. We recently reported that the pro-apoptotic effect of H2S donors is related to their...
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Polysaccharide from Inonotus obliquus inhibits migration and invasion in B16-F10 cells by suppressing MMP-2 and MMP-9 via down-regulation of NF-kB ... Song,In,Gyu,... - 《Oncology Reports》 被引量: 0发表: 2014年 Polysaccharide from Inonotus obliquus inhibits migration and invasion in B16-F1...
TRAIL-DR5 interaction by NFkB pathway induces metastatic potential. Lung metastasis of intravenously inoculated B16F10 mouse melanoma cells stimulated without (left panels) or with TRAIL (right panels) was visualized by bioluminescent imaging in mice...
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DNA binding activity of NF-κB, CREB, AP-1, and NF-IL-6 was measured using specific transcription factor assay kits. IL-6 expression was measured by RT-PCR, and silencing was achieved by transfection of anti-IL-6 small interfering RNA. GSH was determined by HPLC. Cell death analysis was...
In addition, the levels of p-PI3K, p-Akt, NF-κB, and MMP-9 were decreased, while the PI3K and Akt were not significantly changed. These results indicate that GBEE can inhibit the metastasis of B16-F10 melanoma via multiple links and the molecular mechanism involved the regulation of PI3K...
The TNF-R1-associated DD binding protein, TRADD, acts as a platform for the recruitment of defined signalling proteins mediating the canonical TNF-induced activa- tion pathways for caspases and NF-kB (reviewed by Wilson et al, 2009 ). In contrast, only few downstream targets of FAN have ...
10.1007/s00018-010-0283-0. Article PubMed Google Scholar Li-Weber M: Targeting apoptosis pathways in cancer by Chinese medicine. Cancer Lett. 2010, Google Scholar Gyrd-Hansen M, Meier P: IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. Nat Rev Cancer. ...
Binding of HMGB1 to TLR-2, TLR-4, or RAGE on macrophages and dendritic cells (DCs) induces production of proinflammatory cytokines through NFkB activation and/or type 1 interferon production through activation of the transcription factor interferon regulatory factor-3 (IRF3) [1, 3]. These ...