acute cerebral folate deficiencybirth defectsneural tube defectsfolic acid food fortificationAlthough deficiencies of vitamin B12 (aka, cobalamin) and folate can present similarly with megaloblastic anemia, vitamin B12 alone causes neuropsychiatric disorders. Therefore, replacement of the correct vitamin is ...
(2017). Association between the MTHFR C677T polymorphism, blood folate and vitamin B12 deficiency, and elevated serum total homocysteine in healthy individuals in Yunnan Province, China. Journal of the Chinese Medical Association : JCMA, 80(3), 147–153. doi.org/10.1016/j.jcma. [15] Al-Bata...
9. Devalia V, Hamilton MS, Molloy AM; British Committee for Standards in Haematology. Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Br J Haematol. 2014;166(4):496-513. 10. Moridan...
SummaryIntroductionAnemia and macrocytosis are well-defined expected hematologic findings of vitamin B12 and folate deficiency; however, some previous studies did not show a significant association of subnormal B12 with anemia and macrocytosis.MethodsWe retrospectively analyzed 17713 laboratory patient records...
Elevated plasma tHcy concentrations were positively related to serum Cys-C concentrations.ConclusionsHyperhomocysteinemia in chronically exposed workers was primarily induced by vitamin B12 and folate deficiency. This metabolic change might be associated with renal dysfunction in chromate processing workers ...
p> Background: The most common reason for assessing vitamin B12 and folate status is a clinical suspicion of deficiency along with the haematological abnormality of macrocytic anaemia.However, there is often a lack of a precise clinical or haematological picture to guide the appropriate investigation...
Many children in low- and middle-income countries may have inadequate intake of vitamin B12 and folate; data confirming these inadequacies are limited. We used biochemical, demographic, behavioral and anthropometric data to describe the folate and vitamin B12 concentrations among six- to 23-month-old...
folatehomocysteinemethylmalonic acidtest utilizationvitamin B12Background Current guidelines pertaining to diagnosing macrocytic anemia in association with vitamin B12 and folate deficiency recommend that vitamin B12, folate, homocysteine, and methylmalonic acid assays should be assessed concurrently due to their...
Green, R. Metabolite assays in cobalamin and folate deficiency. Baillieres Clin. Haematol. 8, 533–566 (1995). Google Scholar Green, R. Screening for vitamin B12 deficiency: caveat emptor. Ann. Intern. Med. 124, 509–511 (1996). Google Scholar Carmel, R. Subclinical cobalamin deficiency...
Based on biochemical evidence, a high prevalence of biochemical evidence of vitamin B12 or folate deficiency has been reported in a number of areas in the world. The evidence that these biochemical abnormalities lead to a comparable prevalence of anemia is reviewed. The overall contribution of vitam...