which has proven to be effective in the treatment of non-Hodgkin lymphoma and CLL through B-cell depletion.91 Since Bregs express low levels of CD20, CD20- depletion mostly enriched tumor-induced Bregs and subse- quently enhanced metastasis in a murine model of breast cancer.91,92 In additi...
Moreover, mantle cell lymphoma (MCL) patients cannot maintain remission even after high dose immunochemotherapy followed by autologous stem cell transplantation (ASCT) [13]. Ibrutinib has improved progression-free survival (PFS) [4] and rituximab maintenance prolonged duration of response in relapsed ...