Notably, this pathway was present in young mice but was absent in old mice, indicating that the age of the micro environment profoundly influences the progression of B-ALL.doi:10.1182/blood.2021013699J.ZhangD.LucasBloodBlood
proven to contribute to the fusion protein's trans-regulatory activity, co-factors recruitment and homodimerization. Furthermore, targeting MH-driven transactivation of HDAC family using HDAC inhibitor Panobinostat improved the o...
TSLPR has limited surface expression on normal tissues. TSLPR-targeted CAR T cells thus represent a potent oncoprotein-targeted immunotherapy for high-risk ALL.
The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. B7-2 is a recently discovered, second ligand for the CTLA-4/CD28, T cell signaling system. Using the GL-1 rat monoclonal antibody (mAb), we monitored...
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Clinico-biological features of patients included in this study 635 ID Age at dx Gender Cytogenetics RAS WBC CNS % blasts Disease Mice Mice CNS Mice CNS (months) status 103cell/μl disease NG2+ status graft (1°) (2°) 01 ND F MLL-AF4 NA 185 Neg 38 CR Neg Neg ND 02 7 M MLL-...
In B-ALL cells from these mice, SYK was phos- phorylated and inhibition of SYK with either fostamatinib (which has been clinically tested in rheumatoid arthritis and B cell lymphoma) or BAY61‑3606 (a tool compound) decreased SYK phosphorylation and cell proliferation. Moreover, when ...
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In lenalidomide-sensitive mice crossed with TP53–/– knockout mice that underwent transplantation with both TP53 mutant and wild-type hematopoietic progenitor cells, lenalidomide led to preferential outgrowth of TP53 mutant cells in all blood lineages.30 A case of lenalidomide-dependent MDS with the ...
While the T315I CMLmice were resistant to imatinib with a median survival of 21days, IPI-504 (50 and 100 mg/kg, PO TIW) demonstrated dose-dependentprolonged survival of these mice by 30 and 70 days, respectively(p<0.001 for both doses). Both imatinib and IPI-504 similarlyprolonged ...