针对这一问题,百奥赛图在B-NDG背景下开发了一种新型B2m基因敲除小鼠B-NDG B2m KO mice plus,该小鼠缺乏鼠源MHC I类分子的表达,但表达由鼠B2m和Fcgrt基因融合表达的鼠源FcRn蛋白,最大程度避免影响FcRn对抗体的循环代谢功能;为了消除MHC II类分子的表达,我们还在相同的B-NDG背景下开发了一种H2-Ab1基因敲除小鼠,...
在注射后2周,与B-NDG小鼠相比,B-NDG hIL15小鼠的外周血中具有更高比例的人NK细胞,并且在注射后的6周仍然可以维持较高的水平。 图4:人NK细胞在B-NDG hIL15小鼠中重建后检测各类免疫细胞的比例 03 B-NDG hTHPO mice 无需辐照,进行人CD34+HSC重建 分别在未经...
To overcome this limitation, we engineered B-NDG B2M knockout mice plus (NOD.Cg-Prkdcscid Il2rg-/-/Bcgen) that is deficient in MHC I expression but expresses the B2M gene fused in the FcRn gene. In the present study we demonstrate the phenotypic changes in the immune system of the ...
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