a B-cell maturation antigen- directed chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study. Lancet, 2021; 398(10297):314-324
Cancer/testis antigens on the X chromosome (CT-X antigen); cancer/testis antigen 1B (CTAG1B; NY-ESO-1); melanoma antigen family A (MAGEA)Studies in human cancer samples suggest that vaccines based on CT-X antigens could help treat estrogen receptor (ER)- and progesterone receptor (PR)...
In tumour-associated tertiary lymphoid structures, T cells and B cells interact and undergo cooperative selection, specialization and clonal expansion. Importantly, B cells can present cognate tumour-derived antigens to T cells, with the functional consequences of such interactions being shaped by the ...
Community Oncology Connections™: Contextualizing Novel Immunotherapy for Advanced Melanoma – How Do TIL Therapies Fit into Practice? | Wisconsin Apr 1st 2025 - May 10th 2025 online-activity View More Video Community Oncology Connections™: Community Oncologists’ Role in Selecting Optimal Oral SERD...
①效应性B细胞(effector B cell,Beff)可产生自身抗体,如类风湿因子(rheumatoid factor,RF)和抗瓜氨酸蛋白抗体(anti-citrulline protein antibody,ACPA)等,这些抗体形成免疫复合物,沉积在关节中,并通过补体和细胞激活促进炎症过程;②B细胞作为有效的抗原提呈细胞(antigen presenting cell,APC),通过共刺激分子的表达激活...
For example, a whole cell vaccine that’s hitting multiple targets may be better than a single-antigen target. The target is important, and BCMA is a good target in terms of differentiating plasma cells from many other cells in the body. However, it is not perfect. Eliminating all BCMA ...
Bruton’s tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic signaling that is critical for proliferation and survival of leukemic cells in many B cell malignancies. BTK was initially shown to be defective in the primar
Intriguingly, activated CTLs can also engage with soluble CD27 secreted by CD19+ B cells, which promotes their survival and proliferation, suggesting a ‘helper’ role of B cells in the tumour immune response [31]. In several recent studies on TLSs in cancer, TLSs have been found to be...
中文名称:NALM-6人急性B淋巴白血病复苏细胞(附STR鉴定报告) 英文名称:NALM-6 保存条件: 常温培养或液氮冻存 纯度规格: NALM-6人急性B淋巴白血病复苏细胞(附STR鉴定报告) 产品类别: 生物试剂 "NALM-6人急性B淋巴白血病复苏细胞(附STR鉴定报告) 细胞生长:悬浮 细胞传代方法:1:2-1:3传代;每周换液2-3次。 细胞...
Targeting BCL2 overcomes resistance and augments response to aurora kinase B inhibition by AZD2811 in small cell lung cancer [J]. Clin Cancer Res, 2023, 29(16): 3237-3249. [49] Hauf S, Cole R W, Laterra S, et al. The small molecule hesperadin reveals a role for aurora B in ...