We previously demonstrated that β-lapachone (β-Lap) exerts stronger anticancer activity on oxaliplatin-resistant HCT116 colorectal cancer cells (Oxp-R-HCT 116 cells) than parental HCT116 cells (p-HCT 116 cells) by downregulating the oxaliplatin resistance-related upregulated proteins (Oxp-RR-...
二0酸核糖羧化酶/加氧酶(Rubisco)试剂盒 紫外分光光度法 25管/24样 4,9-Dihydroxy-α-lapachone 中文名: 分子式:C15H14O5 度:98.0% 人类白细胞抗原B27(HLA-B27)ELISA检测试剂盒HumanleucocyteaigenB27,HLA-B27 96T/48T 5,6-FAM;5(6)-羧基荧光素 5(6)-Carboxyfluorescein 质量规格:0.95 人类白细胞抗原C...
NQO1生物激活药物,例如β-lapachone,具有独特的醌结构,被NQO1催化后生成活性氧(ROS)导致未修复的DNA损伤和细胞程序性坏死。然而,由于用药后严重的急性毒性反应,包括溶血性贫血和高铁血红蛋白血症等,使其在不同癌症类型的尝试中以失败告终。...
密度泛函理论(DFT)计算表明,关键的C-C键断裂释药步骤的活化能仅为8.3 kcal/mol,可在生理条件下快速释药,其驱动力可能源自产物的芳构化效应。 作者将该前药策略应用于多个邻醌类抗肿瘤天然产物,代表性的β-lap前药分子具有良好体内...
β-Lapachone (β-Lap) triggers apoptosis in a number of human breast and prostate cancer cell lines through a unique apoptotic pathway that is dependent up... C Tagliarino,JJ Pink,K Reinicke,... - 《Cancer Biology & Therapy》 被引量: 153发表: 2003年 Efficacy of beta-lapachone in pancre...
β-lapachone (β-lap), an NAD(P)H:quinone oxidoreductase 1 (NQO1) targeting antitumor drug candidate in phase II clinical trials, is metabolically eliminated via NQO1 mediated quinone reduction and subsequent UDP-glucuronosyltransferases (UGTs) catalyzed glucuronidation. This study intends to explore...
人亮氨酰氨基肽酶(LAP)ELISA Kit Dehydro-alpha-lapachone 5297-92-4 C5H2O3 ≥98%人链激酶(SK)ELISA Kit Deoxylapachol 3568-90-9 C5H4O2 ≥98%人核糖核酸酶(RNASE)ELISA Kit Deoxyshikonin 43043-74-9 C6H6O4 ≥98%人过氧化脂质/乳过氧化物酶(LPO)ELISA Kit Dimethylacrylshikonin 24502-79-2 C2H22O...
Objective and design The purpose of this study was to evaluate the anti-inflammatory and anti-arthritic activities of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (β-lapachone; β-lap)...doi:10.1007/s00011-012-0557-0Marília Maria Sitônio...
Futile cycle b‐lapachone recycling produces elevated superoxide levels, resulting in massive levels of hydrogen peroxide that lead to substantial DNA damage and endoplasmic reticulum Ca2+ release. DNA damage and Ca+2 entry into the nucleus leads to the hyperactivation of poly(ADP‐ribose) polymerase...
The clinical experimental agent, β-lapachone (β-lap; Arq 501), can act as a potent radiosensitizer in vitro through an unknown mechanism. In this study, we analyzed the mechanism to determine whether β-lap may warrant clinical evaluation as a radiosensitizer. β-Lap killed prostate cancer ...