结果显示:在B-hPD-1/hLAG3纯合鼠活化的CD4+T与CD8+T细胞里均可检测到hLAG3/hPD-1+细胞。 PD-1(Keytruda)抗体与抗人LAG3抗体联用体内药效 利用B-hPD-1/hLAG3小鼠进行抗人抗体药效验证实验 将小鼠结肠癌细胞MC38移植到B-hPD-1/hLAG3纯合小鼠皮下,待肿瘤体积约150±50mm3时将动物入组至对照组和治疗组...
将小鼠结肠癌细胞MC38移植到B-hLAG3纯合小鼠皮下,待肿瘤体积约150±50mm3时将动物入组至对照组和治疗组(n=10)。 结果显示:抗人LAG3抗体(Relatlimab Analog)和鼠源PD-1抗体联用对肿瘤生长具有明显的抑制作用。A. 肿瘤平均体积±SEM,B. 小鼠平均体重±SEM。 百奥赛图利用自主开发的B-hPD-L1/hLAG3双人源...
图3.将小鼠结肠癌mc38细胞移植到b-hpd-1/hox40纯合小鼠体内建立皮下肿瘤模型,待肿瘤体积约150±50mm3时将动物分组(n=6)。 结果显示:抗人pd-1抗体keytruda和抗人ox40抗体联合用药组与单独用药组相比表现出更为明显的肿瘤抑制效果,证明b-hpd-1/hox40小鼠是评估人pd-1抗体与人ox40抗体联合用药的有力工具。
图1. 流式检测hCD3EDG 纯合小鼠中人源CD3E/CD3D/CD3G的表达。 图2. 在hCD3EDG纯合子小鼠荷瘤(MC38-hCLDN18.2)模型体内,检测anti-CD3×Claudin18.2双特异性抗体的肿瘤抑制效果。 图3. 在hCD3EDG纯合子小鼠荷瘤(MC38-hEpCAM)模型体内,检测OKT3(人源CD3抗体)和anti-CD3×EpCAM双特异性抗体的AICD(活化诱...
Antitumor activity of anti-human PD-L1 antibody in B-hPD-1/hPD-L1 mice.(A) Anti-human PD-L1 antibody atezolizumab (in house) inhibited B-hPD-L1 MC38 plus tumor growth in B-hPD-1/hPD-L1 mice. Murine colon cancer B-hPD-L1 MC38 plus cells (5×105) were subcutaneously implanted into...
(A) anti-human PD-L1 Atezolizumab (in house) combined with anti-human Triagolizumab(in house) inhibited MC38-hPD-L1 tumor growth in B-hPD-1/hPD-L1/hTIGIT mice. Murine colon cancer MC38-hPD-L1 cells (5×105) were subcutaneously implanted into homozygous B-hPD-1/hPD-L1/hTIGIT mice(...
例如,MC38结肠癌细胞系来源于C57BL/6,MC38细胞则可以很容易地移植到C57BL/6小鼠中(即 cell derived allograft, CDA模型),或者是对基因修饰自发肿瘤模型的肿瘤组织接种至同背景的野生型小鼠体内(即 GEM-derived allograft, GDA模型),因为C57BL/6小鼠具有完整的免疫系统,因此对评估免疫细胞对抗肿瘤的治疗方法非常有...
研究人员在携带MC38-hPDL1-hCD73异种移植物的C57BL/6-hPD-1/hPD-L1/hCD73转基因小鼠中研究了AK131的体内抗肿瘤活性。研究显示,AK131可显著抑制肿瘤体积生长,具有强大的抗肿瘤活性。
Immune profiles of B-hPD-1/hPD-L1/hTIGIT mice were similar to those in wild-type C57BL/6 mice, and abnormalities were not observed. Importantly, we showed that combining anti-human PD-L1 and anti-human TIGIT antibodies significantly inhibited the growth of MC38-hPD-L1 tumor cells implanted...
将改造过的小鼠结肠癌mc38细胞(人源化hvem并去除小鼠hvem)移植到b-hbtla纯合小鼠体内建立皮下肿瘤模型,待肿瘤体积约150±50mm3时将动物入组至对照组和治疗组(n=6)。 结果显示:相同剂量下,不同抗人btla抗体展现对肿瘤的抑制效果不同;同一抗人btla抗体,不同剂量下也展现出不同抑瘤效果。a. 肿瘤平均体积±se...