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The research sheds light on the biochemical and genetic mechanisms underlying PA biosynthesis, offering insights for engineering PAs with specific properties. (79) Flavonols in the glasshouse plant Rheum nobile TWEET: Quercetin-derived flavonols support UV protection in the incredible alpine plant, Rheum...
A comparison of the mean values for the three parameters, namely, roll, twist and slide, which contribute predominantly to the DNA curvature and superhelical pitch, for the nucleosome dataset with those for the free B-DNA dataset [25] sheds some light on the role played by the histone prote...
from the group of less potent [3H]preS1 binding inhibitors (IC50 = 11–50 µM), some were poorly selective (e.g.18) and others were highly selective (e.g.13,17,19and30). Taken together, these data clearly indicate structure–activity relationships of the betulin derivatives ...
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https://doi.org/10.1182/blood.2019002538Get rights and content Under an Elsevier user license open archiveAbstract B-cell acute lymphoblastic leukemia (ALL; B-ALL) is the most common pediatric cancer, and high hyperdiploidy (HyperD) identifies the most common subtype of pediatric B-ALL. Despite...
In summary, our study identifies for the first time the tremendous therapeutic potential of pyrotinib combined with chrysin in treating HER2-positive breast cancer but also sheds light on the functional role of miR-16-5p/ZBTB16/G6PD axis in the anti-HER2 therapeutic process. Together, our stud...
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This comprehensive analysis sheds light on DLBCL development mechanisms and metabolic targets, offering insights for precise immune therapies targeting tumor-specific metabolic pathways. In our study, four glycolysis genes (ENO1, STMN1, PKM, and CDK1) have been previously reported to be associated ...