30The diagram below shows some cells.Cell A Cell B Cell C(a) Which cell part is found in the cytoplasm of Cell A but not in Cell B and C?Give a reason for the absence of the cell part in Cell B and C.[1](b) Cell A, B and C are placed in a container of water. After ...
“pure” T-ALL, whereashMYC-1contained some B cells but mostly T-ALL cells, and thathMYC-2samples contained the highest percentage of B and/or B-ALL cells relative to T-ALL cells. Alternatively, leukemias can express aberrant markers [22], andhMYCmight de-differentiate ALL, obscuring ...
Overall, we examined articles which introduced epitopes that were identified by B and T cells and were extracted from viral antigenic proteins such as S, M, N, and E. Also, these selected epitopes needed to be analyzed in terms of antigenicity, allergenicity, and physiological properties and ...
T cells expressing the CAR used in this work (CAR-BCMA) specifically recognized BCMA-expressing cells. Twelve patients received CAR-BCMA T cells in this dose-escalation trial. Among the 6 patients treated on the lowest 2 dose levels, limited antimyeloma activity and mild toxicity occurred. ...
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Extended loop extrusion across the immunoglobulin heavy-chain (Igh) locus facilitates VH-DJH recombination following downregulation of the cohesin-release factor Wapl by Pax5, resulting in global changes in the chromosomal architecture of pro-B cells. He
Chimeric antigen receptor (CAR) T-cells targeting CD19 demonstrate remarkable efficacy in treating B-lineage acute lymphoblastic leukemia (BL-ALL), yet up to 39% of treated patients relapse with CD19(−) disease. We report that CD19(−) escape is ass
Backgroundγδ T cells, like αβ T cells, are components of all well-studied vertebrate immune systems. Yet, the contribution of γδ T cells to immune responses is poorly characterized. In particular, it has not been resolved whether γδ cells, independent of any other T cells, can hel...
Control of HBV infection is mediated mainly by cytotoxic T cells, but B cells are required for antigen presentation and B-cell depletion by rituximab may also disrupt CD8 cytotoxic killing of HBV-infected hepatocytes. Much of the evidence used to classify rituximab as very high risk of causing ...