Distinguishing B―PLL from pleomorphic mantle cell lymphoma, splenic marginal zone lymphoma, and CLL with an increased number of prolymphocytes can be difficult on morphological grounds. 【翻译】B幼淋巴细胞白血病与母细胞性套细胞淋巴瘤(MCL)、脾脏边缘...
Because elderly patients wereexpected to die with CLL rather than from it, the mainstay of therapy was to palliate symptoms withoral, alkylating drugs, such as chlorambucil.However, treatment with such drugs not only could not cure the disease, but also could shortensurvival if given to ...
①效应性B细胞(effector B cell,Beff)可产生自身抗体,如类风湿因子(rheumatoid factor,RF)和抗瓜氨酸蛋白抗体(anti-citrulline protein antibody,ACPA)等,这些抗体形成免疫复合物,沉积在关节中,并通过补体和细胞激活促进炎症过程;②B细胞作为有效的抗原提呈细胞(antigen presenting cell,APC),通过共刺激分子的表达激活...
B-cell depleting therapy (BCDT) has revolutionised the treatment of B-cell malignancies and autoimmune diseases by targeting specific B-cell surface antige
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12 cases with lactate dehydrogenase higher than the normal value limit, 9 cases with international prognostic index scores ≥ 4, 13 cases with B symptoms, 10 cases with Ki-67 positive index ≥ 80%, 15 cases with more than 1 lymph extra nodal organ involvement and 8 cases with tumor mass ...
B-Cell Lymphoma Symptoms B-cell lymphoma doesn’t always cause symptoms. If you have a slow-growing type, it might take months or years before symptoms start. As abnormal B cells multiply, they can cause areas that have lymph tissue to get bigger. Sometimes you can even feel these lymph ...
Because elderly patients wereexpected to die with CLL rather than from it, the mainstay of therapy was to palliate symptoms withoral, alkylating drugs, such as chlorambucil.However, treatment with such drugs not only could not cure the disease, but also could shortensurvival if given to ...
, etc, and we ask very basic questions,” Sobhanian said. “Since we’re pharmacists, we don’t go into the weeds, but we assess the patients’ symptoms with questions [such as], ‘Compared with how you were before treatment, where are you in terms of these particular symptoms?
In most patients, the diagnosis of CLL is an incidental one, made when a blood count is performed without any clinical suspicion of leukemia. These patients have no abnormal physical findings nor any symptoms resulting from the leukemia. In other patients with more advanced disease, the typical ...