B-cell lymphoma is a type of blood cancer that affects the B lymphocytes of the immune system. They usually arise in the lymph nodes or in other lymphoid tissue, such as the spleen, bone marrow, blood or other organs. B-cell lymphomas are composed of large B lymphoid cells whose nuclear...
弥漫性大B细胞淋巴瘤(DLBCL,diffuse large B-cell lymphoma)中激活致癌B细胞受体(BCR)信号的病理性机制,在很大程度上都是未知的。近日,一篇发表在国际杂志Blood Cancer Discovery上题为“Disruption of KLHL6 Fuels Oncogenic Antigen Receptor Signaling in B-cell Lymphoma”的研究报告中,来自芬兰赫尔辛基大学等机构的...
Despite recent advances in frontline therapy for diffuse large B-cell lymphoma (DLBCL), at least a third of those diagnosed still will require second or further lines for relapsed or refractory (rel/ref) disease. A small minority of these can be cured wi
本文研究揭示了KLHL6的反复突变改变B细胞受体并诱导弥漫性大B细胞淋巴瘤的可操作表型特征背后的分子机制。 弥漫性大B细胞淋巴瘤(DLBCL,diffuse large B-cell lymphoma)中激活致癌B细胞受体(BCR)信号的病理性机制,在很大程度上都是未知的。近日,一篇发表在国际杂志Blood Cancer Discovery上题为“Disruption of KLHL6 F...
2 Pasqualucci L, Dalla-Favera R. Genetics of diffuse large b-cell lymphoma.Blood2018; 131: 2307–2319. 3 Mondello P, Tadros S, Teater M, Fontan L, Chang AY, Jain Net al.Selective Inhibition of HDAC3 Targets Synthetic...
已在Cell, Nature, Cancer Cell, Nature Biotechnology, Nature Genetics, Cell Stem Cell, Nature Cell Biology, Science Translational Medicine, Molecular Cell等期刊上发表一系列重要论文,近期招聘若干名有 RNA 研究、mRNA-based 治疗、...
Lymphomas are "blood cancers" in lymphoid organs.Characteristics B-cell lymphoma is the most common form of hematological malignancy, or "blood cancer," in the United States. Taken together, lymphomas represent 5.0 % of all cancers in the United States and 55 % of all blood cancers. B-cell...
What Is B-Cell Lymphoma? B-cell lymphoma is a cancer that forms in your white blood cells called lymphocytes. These cells are made by your lymphatic system, which plays an important role in immunity. The lymphatic system includes a few organs and runs across your entire body, so B-cell ...
参考文献 Alexandra E Rojek, Sonali M Smith.Evolution of therapy for limited stage diffuse large B-cell lymphoma.Blood Cancer J . 2022 Feb 24;12(2):33. doi: 10.1038/s41408-021-00596-z.
[1] Viardot A, Goebeler ME, Hess G, Neumann S, Pfreundschuh M, Adrian N, et al. Phase 2 study of the bispecific T-cell engager (BiTE) antibody blinatumomab in relapsed/refractory diffuse large B-cell lymphoma. Blood 2016;127:1410–6. ...