Follicular and marginal zone B cells differ in their development and in their role in subverting pathogens with marginal zone B cells bearing more innate-like properties, such as production of proinflammatory cytokines. Here authors show via B-cell specific genomic deletion mouse models that the tran...
diffuse large B-cell lymphomahigh grade B-cell lymphomadouble hit lymphomaMYCDiffuse large B-cell lymphoma (DLBCL) transformed from follicular lymphoma (FL) (tDLBCL) has been traditionally associated with an aggressive course, but more recent studies have shown longer survivals. The clinical ...
B cell lymphoma-6 (Bcl6) while they are still in the area at the edge of the follicles[36]. The T cells then start to express T follicular helper cell markers such as programed death-1, GL7 antigen, and the receptor for B cell zone chemokine CXCR5, which mediates their subsequent ...
B-cell lymphoma is a type of blood cancer that affects the B lymphocytes of the immune system. They usually arise in the lymph nodes or in other lymphoid tissue, such as the spleen, bone marrow, blood or other organs. B-cell lymphomas are composed of large B lymphoid cells whose nuclear...
BCR-mediated tonic signaling is an indispensable requirement for the survival of follicular B (FOB) cells and Burkitt lymphoma (BL) cells. FOB cells of the I-A12% mutant mouse express unfolded protein response and are extremely short lived. Among the myriad molecules activated by unfolded protein...
B-NHL 可累及任何器官,致病机制、临床表现和病程具有异质性,其恶性程度从惰性至侵袭性极强不等。CD20 单抗联合常规化疗仍是大多数 B-NHL 亚型的标准治疗方案,大多数患者可从中获得持久的疗效;但高危患者容易早期复发,临床预后很...
We examined stimuli which are required for the induction of in vitro proliferation of follicular lymphoma cells, a low grade non-Hodgkin's B cell lymphoma characterized by a specific chromosomal translocation, t(14;18)(q32;q21), and by in vivo growth of the lymphoma cells in germinal center...
该研究入组22例复发或难治B-NHL患者【包括13名DLBCL患者、7名滤泡性淋巴瘤(follicular lymphoma, FL)患者以及2名边缘区B细胞淋巴瘤(marginal zone B-cell lymphoma,MZL)患者】。IM19产品经过严格的放行检测后,分别以5×105/kg(3例),1×106/kg(13例)和3×106/kg(6例)的剂量静脉输注入患者体内。治疗后3个...
Hodgkin lymphoma (NHL), which is the seventh-most prevalent cancer in the United States and has the sixth-highestmortality rate[1]. The most frequently diagnosed B-cell lymphoma subtypes include diffuse large B-cell lymphoma (DLBCL; 31% of diagnosed lymphomas) andfollicular lymphoma(FL; 22%) ...
1.NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). B-Cell Lymphomas. Version 1.2024 2.Colombat P, Salles G, Brousse N, et al. Rituximab (anti-CD20 monoclonal antibody) as single first-line therapy f...