Mechanisms regulating B cell development, activation, education in the germinal center (GC) and differentiation, underpin the humoral immune response. Protein arginine methyltransferase 5 (Prmt5), which catalyzes most symmetric dimethyl arginine protein
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B-cell receptors (BCRs) are a crucial player in the development and activation of B cells, and their mature forms are secreted as antibodies, which execute functions such as the neutralization of invading pathogens. All current analytical approaches for BCRs solely investigate the BCR sequences ...
Of interest, B-IL4R subtypes highly expressed mature B-cell characteristic genes (IGHD) and highly expressed IL4R, which has been reported to be highly expressed in naïve B cells, suggesting that B-IL4R may be in the intermediate state of B-cell development and transformation (Fig. 2...
B Cell DifferentiationOverview Diagram Reagent Solutions What Are B Cells? B cells, also known as B lymphocytes, develop from hematopoietic precursor cells which play a central role in the immune-pathogenesis of glomerulonephritides and transplant rejection. B cells can secrete antibodies through ...
Our previous work provided a comprehensive analysis of B cell development in human bone marrow (Bendall et al., 2014). To characterize mature human B cells in the periphery, we developed a highly multiplexed single-cell screen to quantify the co-expression of 351 surface molecules by using mas...
Figure 7. Leucine dieting represses LARS B cell-mediated colorectal cancer immunoevasion (A–E) Schematic diagram of orthotopic mouse model. The tumor-bearing mice were randomly assigned to five groups. Group 1, mice with normal diet (control, #1). Group 2, mice with leucine-rich diet (1.5...
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