Capsular switching from MenC to MenB among cc11 organisms is concerning because a large MenB cc11 (B:cc11) outbreak has the potential to cause significant morbidity and mortality. This study aimed to assess the potential for licensed and developmental non-capsular meningococcal vaccines to protect...
Mutations in STAT1 gene have been shown to be in association with multifocal osteomyelitis in patients with Mendelian susceptibility to mycobacterial disease (MSMD), due to impaired inhibition of osteoclast differentiation and bone resorption24,25. We also detected there are multiple protein-altering vari...
a crucial protein of B-cell receptor was upregulated both in the blood and cerebrospinal fluid of NMOSD patients. Blockade of BTK with zanubrutinib, a highly specific BTK inhibitor, mitigated the activation and maturation of B cells and reduced production of causal aquaporin-4 (AQP4...
Microscopic examination of sections taken from the heart, lungs, kidneys, liver and spleen showed multifocal intravascular collections of large lymphoid cells with prominent central nucleoli and moderately abundant amphophilic cytoplasm. No extravascular infiltrates were identified. In the lung, the large ...
Robert A Schwartz3 and Nancy L Harris1 1Department of Pathology, James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, MA, USA; 2Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA and 3Department of Pathology, Manchester Memorial Hospital, Manchester...
The final diagnosis was T-cell/histiocyterich B-cell lymphoma. A multifocal or micronodular pattern of splenic infiltration is a recognized feature of this lymphoma. The role, if any, of antiviral therapy in this lymphoma subtype in a hepatitis C-positive patient is unknown....
The 75 nm thick ultrathin sections were stained with methanolic uranyl acetate and lead citrate, then visualized by TEM (TECNAIG2, FEI Company, Hillsboro, Oregon, USA). Statistical analysis Statistical analysis was conducted with SPSS 17.0 software (IBM, Chicago, USA). Animal groups were ...
Autoimmune uveitis, Balo disease/Balo concentric sclerosis, Behçet's disease, Berger's disease, Bickerstaff's encephalitis, Blau syndrome, Bullous pemphigoid, Cancer, Castleman's disease, Celiac disease, Chagas disease, Chronic inflammatory demyelinating polyneuropathy, Chronic recurrent multifocal osteomyel...
We developed a non-destructive and rapid whole-mount bone staining method for small fish, Xenopus laevis, and rodent fetuses (RAP-B). RAP-B does not require skin or soft tissue removal. However, RAP-B requires hair removal from hairy animals, such as adu
This basic model is not adequate for the herpes virome, especially after hematopoietic stem cell transplantation (HSCT), due to continuous, usually multifocal antigenic stimulation, various donor serostatuses, immunosuppression, and individual immunoreconstitution. Methods: A case–control study was ...