uncomplicated AOM in children.Methods: Children aged 6 months to 12 years with new-onset AOM were randomly assigned to receive either a single 30-mg/kg dose of azithromycin or standard-dose amoxicillin/clavulanate (45 mg/kg per day divided BID for 10 days) in a double-blind, double-placebo...
Single- dose (30 mg/kg) azithromycin compared with 10-day amoxicillin/ clavulanate (45 mg/kg per day) for the treatment of uncomplicated acute otitis media. Curr Ther Res. 2003;64 (suppl A):A30 -A42Block SL, Arrieta A, Seibel M, et al. Single- dose (30mg/kg) azithromycin compared...
regius), the authors found that the drug is distributed and excreted similar to humans, and the dose, 10 mg/kg orally, is given at different frequencies based on the location of the infection: skin, every 3 days; respiratory tract, every 5 days; and liver/kidneys, every 7 days.41 View...
A 10 mg/kg body weight; B 15 mg/kg body weight; C 20 mg/kg body weight; D allometric dosing, consisting of a flat dose per weight band according to Table 5. This dosing scheme results in a consistent exposure across all weight bands Full size image Comparison of cases and controls ...
are similar to or less than the highest recommended adult human dose. This effect has been shown to be reversible after cessation of azithromycin treatment. Based on the pharmacokinetic data, phospholipidosis has been seen in the rat (50 mg/kg/day dose) at the observed maximal plasma concentrati...
For pediatric patients 6 months and older, Zmax should be taken as a single dose of 60 mg/kg (equivalent to 27 mg/lb) body weight. The Zmax dose in mL is equivalent to the child's weight in lb (1 mL/lb dose, see Table 1 below), for a body weight of less than 75 lb (34 ...
Azithromycin concentrations in the tonsils of 56 pediatric patients, treated with 10 or 20 mg of the drug per kg of body weight for 3 days, were compared. Azithromycin levels in plasma and tonsil samples were determined up to 8.5 days after the last dose. The 20-mg/kg regimen resulted in...
This study was a 1:1 individually randomized placebo-controlled trial comparing single dose azithromycin (20 mg/kg) to matching placebo. This study was registered at clinicaltrials.gov before recruitment of the first participant (ClinicalTrials.gov NCT03676751, registered 19/09/2018). Study sett...
dose of 1g; this dose also appears effective in the treatment of chancroid and uncomplicated gonorrhoea. In paediatric patients, an oral dosage regimen of 10 mg/kg on the first day and 5 mg/kg for a further 4 days is recommended. However, children weighing more than 45kg should receive ...
Among 2,922 adults scheduled to receive multiple-dose azithromycin in clinical trials, the treatment was discontinued because of side effectsmchiefly gastrointestinal symptoms--in 22 patients (0.8%), significantly fewer than in erythromcyin recipients (24/450, 5.3%) or in those receiving any ...