The current manuscript describes the catalysts in click chemistry reactions, mechanism insights and use of other metals beyond copper associated with Azide-Alkyne Cycloadditions (AAC). Due to their biological importance and several applications in various areas of science, significant efforts have been ...
Cu-catalyzed azide-alkyne cycloadditions can easily be achieved at ambient temperature with high efficiency. The catalyst produces significantly lower copper contaminants compared to homogeneous copper complexes. Iron not only behaves as support, but also...
The most famous amongst them is the copper-catalyzed azide-alkyne cycloaddition (CuAAC) which opens up outstanding opportunities in various fields of science and technology. Since the development of the CuAAC by Meldal and Sharpless it gained enormous attention not only in the field of chemistry,...
In this study, we combined thiol-ene photopolymerization (TEP) and thermal azide-alkyne cycloaddition click reactions to prepare eugenol-based thermally stable, P-, N-, and Si-containing networks. To this end, we synthesized a P-containing, eugenol-based monomer bearing azide group and a ...
strain‐promoted azide‐alkyne cycloadditionThe preparation of polymers under mild conditions, using highly efficient reactions, allows the incorporation of new, functional monomer units. Here, we explore the use of strain-promoted azide-alkyne cycloaddition (SPAAC) as a polymerization tool. We show ...
点击化学_叠氮炔环加成_Click Chemistry_Azide-Alkyne Cycloaddition “点击化学”是K.B.Sharpless在2001年提出的一个术语,用于描述高产率、广度、仅能产生副产物的反应,这些副产物无需色谱即可去除,具有立体特异性、操作简单、可在易去除或良性溶剂中进行。这一概念是在制药、材料和其他行业对生成用于发现研究筛选的大...
Mechanistic Insights into 1,2,4-Triazine-Accelerated Copper-Catalyzed Azide-Alkyne CycloadditionBerkeley Electronic Press Selected WorksBelinda S. LadyAshleigh L. PrincePoster Presentation at the Southeastern Regional Meeting of the American Chemical Society...
Alkyne-Azide CycloadditionsGlembockyte, Viktorija
为了解决该问题,C. R. Bertozzi等人,通过缺电子的变形烷烃开发出了叠氮-烷烃的环化加成反应(strain-promoted azide-alkyne cycloaddition, SPAAC)。本反应不需要铜催化剂的存在下即可在生物体条件下进行,可以对含有叠氮基团的蛋白质・细胞等进行标记。 扭曲的环烯 – 四嗪的狄尔斯 – 阿尔德反应也可以用于...
CuAAC, copper-catalyzed azide-alkyne cycloaddition. We initially compared the ability to detect AMP modification by VopS between this click chemistry and a mix of anti-T-AMP and anti-Y-AMP antibodies using a NAPPA array displaying ∼2000 human proteins produced from human HeLa lysate based ...