Sazetidine-A, a pre-clinical nAChR drug with agonist and desensitizing effects at α4β2 and α7 nAChRs, has been reported to reduce alcohol consumption and nicotine self-administration in rats when administered at high doses. However, this effect has not been replicated in mice. In this ...
The term “radiosensitizer” refers to an agent that enhances the therapeutic ratio of radiotherapy for similar levels of normal tissue toxicity, which is tantamount to the Holy Grail in radiation oncology and cancer therapy in general because selective cytotoxicity predicts improved patient tolerance a...
Raw materials Preparation Products Azetidine, 2-(2,3-dihydro-1,4-benzodioxin-6-yl)- Suppliers Global( 1)Suppliers SupplierTelEmailCountryProdListAdvantage Taizhou Nanfeng Pharmaceutical Research Institute18616377689nanfengdrug@163.comChina2001058
Nitrogen-containing heterocycles are essential structural components for drug design and are currently incorporated in more than 59% of all pharmaceuticals approved by the US Food and Drug Administration (FDA)1. The majority of these contain five- and six-membered pyrrolidine and pyridine derivatives,...
wrapped with dried ice, and the low temperature products will be delivered with ice bags. As for the products stored at room temperature, they will not be packed with ice bags or dried ice. Delta is committed to providing cost-effective products that facilitate drug delivery with our customers...
Mitigating heterocycle metabolism in drug discovery. J. Med. Chem. 55, 6002–6020 (2012). Google Scholar Shu, Y.-Z., Johnson, B. M. & Yang, T. J. Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery. AAPS J. 10, 178–192 (2008). CAS ...
The present invention relates to an azetidine derivative for use as a Janus kinase (JAK) inhibitor, a drug composition comprising same, a preparation method therefor, and a use thereof in the treatment of JAK-related diseases comprising, for example, inflammatory diseases, autoimmune diseases, and...
Methyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs< ...
The synthesis and evaluation of novel azetidine lincosamides are described. Eleven new (3--TBS-4-oxo-azetidine-2-carboxylic acid and subsequent elaboration then coupled to 7-chloro-1-methylthio-lincosamine. The resulting lincosamides differ from the drug clindamycin in both the size of the ring ...
RO5 Drug-like Natural Product Library L61602703 化合物 产品详情 中国药典收录天然产物库 Chinese Pharmacopoeia Natural Product Library L68002270 化合物 产品详情 中药单体化合物库 Traditional Chinese Medicine Monomer Library L68102939 化合物 产品详情 ...