Gollnick H (1993) Azelaic acid – pharmacology, toxicology and mechanism of action on keratinization in vitro and in vivo. J Dermatol Treat 4:S3–S7Gollnick H. Azelaic acid-pharmacology, toxicology and mech- anisms of action on keratinization in vitro and in vivo. J Dermatol Treat 1993;4:...
The exact mechanism of action of azelaic acid is not known. It is thought that azelaic acid manifests its antibacterial effects by inhibiting the synthesis of cellular protein in anaerobic and aerobic bacteria, especially Staphylococcus epidermidis and Propionibacterium acnes. In aerobic bacteria, azelaic...
Azelaic acid is a topical (applied to the skin) medication used for treatingacne. Its exact mechanism of action is unknown. Azelaic acid may work as an antibacterial agent that blocks protein synthesis and therefore growth ofPropionibacteriumacnes and other bacteria on the surface of the skin that...
▪️ Anti-melanogenic: Regulates pigment production to reduce the appearance of dark spots by inhibiting the action of tyrosinase, an enzyme that controls the production of melanin.¹⁰ How azelaic acid works for your skin So we know the benefits of azelaic acid—but how is it possible...
Mechanism of actionNaturally occurring dicarboxylic acid that is bacteriostatic to Propionibacterium acnes. It also decreases conversion of testosterone to 5{pi}ga-dihydrotestosterone (DHT) and alters keratinization of the microcomedone. It may also be beneficial in the treatment of melasma. The mechanis...
Mechanism Of Action The mechanism(s) by which azelaic acid interferes with the pathogenic events in rosacea are unknown. Pharmacodynamics The pharmacodynamics of azelaic acid in association with the treatment of rosacea are unknown. Pharmacokinetics ...
In addition, azelaic acid has an antiproliferative and cytotoxic effect on the human malignant melanocyte, and preliminary findings indicate that it may arrest the progression of cutaneous malignant melanoma. The mechanism of this selective cytotoxic action of azelaic acid is unclear, but may possibly ...
AZELEX®cream is contraindicated in individuals who have shown hypersensitivity to any of its components. Clinical Pharmacology for Azelex The exact mechanism of action of azelaic acid is not known. The followingin vitrodata are available, but their clinical significance is unknown. Azelaic acid has...
twice-dailyMechanism of actiontopical application of azelaic acid 15% gel to the face was signifi-cantly more effective than twice-daily administration of either its Unknown, but may be related to (direct and indirect) anti-inflammatory propertiesvehicle (two studies) or metronidazole 0.75% gel (...
The exact mechanism of action of azelaic acid is not known. The followingin vitrodata are available, but their clinical significance is unknown. Azelaic acid has been shown to possess antimicrobial activity againstPropionibacterium acnesandStaphylococcus epidermidis.The antimicrobial action may be attributab...