Recent advances in the understanding of the PARPi mechanism of action via stabilization of the PARP-DNA complex (trapping) and of the biological roles of the different PARP family members led to the development
We identified a plausible mechanism of resistance to olaparib in two models, namely a reversion mutation in BRCA2 in PDX474.2OR2 and the expression of a potentially hypo- morphic BRCA2 protein in PDX474.7 (Additional file 4: Fig. S1 and Additional file 2: Supplementary Table S2) ...
Key secondary objectives include safety and tolerability; surgery outcomes; and the change in percentage of Ki-67-positive cells in tumor samples. Exploratory analysis using comprehensive omics approaches are planned to elucidate further insights into the mechanism of action of combination therapy. ...
AZD5305 is a novel selective PARP1 inhibitor that can reduce the hematological toxicity by off-targeting of PARP2. We evaluated the anti-tumor effects and mechanism of action of AZD5305 in breast and gastric cancer cells in vitro.Methods: To investigate the anti-tumor effects of AZD5305, we...