2 Tan DS, Yom SS, Tsao MS, Pass HI, Kelly K, Peled N, et al. The International Association for the study of lung cancer consensus statement on optimizing management of EGFR mutation-positive non- small cell lung cancer: Status in 2016. J Thorac Oncol 2016; 11: 946–63. 3 Oxnard GR...
(Ra)-7induces on-target intrinsic apoptosis.aApoptosis induction in Eμ-Myc lymphoma cells stably expressing human Mcl-1, Bcl-2, Bcl-xL, Bfl-1/A1, or Bcl-w and treated with (Ra)-7for 24 h. Data are shown as mean ± SD (n = 3).bIsothermal dose–response curve of Mc...
Dollars H.K.的总和。 美元 [translate] aThe policies shall provide that, to the extent the insurance is extended to any additional insured, such insurance shall be primary and non-contributing with any other insurance carried by such additional insureds. 政策提供,在程度上保险延伸到所有另外的被...
[4] - Morvay Z.K, Gvozdenac D.D. "Fundamentals for analysis and calculation of energy and environmental performance". Applied Industrial Energy And Environmental Management. [5] - Lipska B. "Projektowanie Wentylacji i Klimatyzacji. Podstawy uzdatniania powietrza" Wydawnictwo Politechniki Śląskie...
JS Scott,T Moss,S Stokes,WM Nissink,T Klinowska 摘要: The estrogen receptor alpha (ERα) is expressed in >70% of breast cancers and is a clinically validated target in oncology. Anti-hormonal therapies that block ER function directly (e.g. tamoxifen) or therapies that block the ...
K Pyo,KK Dong,SW Oh,... - 《Cancer Research》 被引量: 0发表: 2022年 Nanoliposome C6-Ceramide in combination with anti-CTLA4 antibody improves anti-tumor immunity in hepatocellular cancer Combination therapy represents an effective therapeutic approach to overcome hepatocellular cancer (HCC) resistan...
这是一项基于美国癌症研究协会大数据库的汇总分析。研究者一共找到了153例AKT1基因E17K点突变的晚期乳腺癌患者和302例配对好的AKT1基因无突变的晚期乳腺癌病友。 结果显示: 经过其他干扰因素校正后,AKT1基因突变并不影响靶向药CDK4/6抑...
Human PI3K Gene Mutation Fluorescence Polymerase Chain Reaction (PCR) diagnostic kit (Amoy Diagnostics, Xiamen, China) was used for the Pi3KCA mutation detection in this study. This kit detects the 5 most common Pi3KCA mutations: E542K, E545D, E545K, H1047R, H1047L. All experiments were ...
Increased mTORC1 and mTORC2 activity is associated with high levels of downstream pS6K and p4E-BP1, and pAKT levels, respectively (Guertin and Sabatini, 2007; Carew et al, 2011). Thus, the mTOR kinase presents an attractive therapeutic target for anticancer drugs. Rapamycin is a selective ...
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