KRINKE G, FROEHLICH E, HEUMANN M, SCHNIDER K, DA SILVA F, SUTER J et al. (1988) Adjustment of the myelin sheath to axonal atrophy in the rat spinal root by the formation of infolded myelin loops. Acta Anatomica 131, 182-187.
Late active lesions (LA): In these lesions myelin was already destroyed and removed from axons. Macrophages contained degradation products reactive for major myelin proteins, such as PLP, but were negative for MOG or CNPase. Inactive lesions with active border (IA + A): The inactive center of...
An important consideration, that is difficult to assess at the time of cell delivery, is the stage of cellular differentiation of transplanted glia after a period of time in vivo. SCs will differentiate into myelin forming cells quite quickly thus reducing their regenerative/autocrine secretory ...
Neuronal overexpression of Nrg1 induces hypermyelination and demonstrates that Nrg1 type III is the responsible isoform. We suggest a model by which myelin-forming Schwann cells integrate axonal Nrg1 signals as a biochemical measure of axon size....
In the nervous system, myelination of axons enables rapid impulse conduction and is a specialized function of glial cells. Myelinating glia are the last cell type to emerge in the evolution of vertebrate nervous systems, presumably in ancient jawed vertebrates (gnathostomata) because jawless ...
Gas6 enhances axonal ensheathment by MBP+ membranous processes in human DRG/OL promyelinating co-cultures.doi:10.1042/AN20130022Kathleen N. O'GuinRoss C. GruberCedric S. RaineHillary M. GuzikBradford K. PoulosBridget Shafit-ZagardoSAGE Publications...
Gas6 enhances axonal ensheathment by MBP+ membranous processes in human DRG/OL promyelinating co-cultures.doi:10.1042/AN20130022human OPC/DRG co-culturemyelinationoligodendrocytegrowth arrest-specific protein 6The molecular requirements for human myelination are incompletely defined, and further study is ...