Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosisAxonal guidanceCREBDNA hydroxymethylationDNA methylationMultiple sclerosisNeurodegenerationNeuronsSynaptic plasticityDue to limited access to brain tissue, the precise mechanisms underlying neuro-axonal dysfunction in neurological ...
Due to limited access to brain tissue, the precise mechanisms underlying neuro-axonal dysfunction in neurological disorders such as multiple sclerosis (MS) are largely unknown. In that context, profiling DNA methylation, which is a stable and cell type-specific regulatory epigenetic mark of genome ac...
However, in MS lesions a major mechanism of axonal and neuronal damage appears to be related to the action of reactive oxygen and nitrogen species, which may induce neuronal injury through impairment of mitochondrial function and subsequent energy failure. View article The Intrinsic Role of ...
Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease of the central nervous system.1 Axonal impairment has been shown to occur in MS since the publication of postmortem descriptions of the disease.2 More recent pathologic studies3,4 have confirmed that axonal loss is...
While overall neurologic impairment is mild, visual dysfunction, not well captured by the EDSS, accounts for a substantial degree of disability in benign MS. 展开 DOI: 10.1097/WNO.0b013e318240204d 年份: 2012 收藏 引用 批量引用 报错 分享 ...
Levels of NfH(SM135) at baseline and week 3 also strongly correlated with the MBP concentration. This study supports the view that acute inflammation in ON and MS results in axonal pathology and that the latter has a role in determining functional impairment. 展开 ...
This mutation specifically triggers age-related loss of RGCs in transgenic mice, resulting in axonal degeneration and visual impairment [104, 105]. Furthermore, it was observed that overexpressing E50K led to increased expression of LC3-II protein in RGCs and their axons [106]. The formation ...
Axonal and dendritic extension by protopanaxadiol-type saponins from Ginseng drugs in SK-N-SH cells. Jpn J Pharmacol 90: 254–262. Article CAS Google Scholar Tohda C, Tamura T, Komatsu K (2003). Repair of amyloid β(25–35)-induced memory impairment and synaptic loss by a Kampo formula...
in axonal connectivity. In support of this idea, through a quantitative analysis of post-mortem brains, we found a greater average number of axonal spheroids per amyloid plaque and larger PAAS size in individuals with moderate to severe AD, compared with those with mild cognitive impairment (MCI...
Diffusion-tensor imaging implicates prefrontal axonal injury in executive function impairment following very mild traumatic brain injury. 【Key Words】 ML Lipton,E Gulko,ME Zimmerman,... - 《International Journal of Medical Radiology》 被引量: 503发表: 2009年 The chemokine SDF-1 differentially regulat...