(B) Quantification of the length of AnkG shown by immunostaining in WT and tauV337M neurons treated with 10 mM NaCl (Ctrl) or KCl for 48 h. n = 43–72 cells/group from three to five independent experiments. ∗∗∗p < 0.001 by one-way ANOVA and Tukey’s post hoc analysis. ...
The five alleles of this complementation group are Dlar5.1Dlar5.2Dlar5.5Dlar13.1, and Dlar13.2. No viability is seen for any Dlar/Dlar genotype in any allelic or allele-plus-deficiency combination tested (for example, see Table 2). Table 2. Complementation Testing of Dlar Mutations Dlar...
Development of complex neural circuits like the peripheral somatosensory system requires intricate mechanisms to ensure axons make proper connections. While much is known about ligand-receptor pairs required for dorsal root ganglion (DRG) axon guidance,
the failure of Ank2-XL to restrict MT organization results in the formation of large, stable MT aggregates that interfere with NMJ development. The latter model would predict that weakening MT-crosslinking activity provided, for example, by MAPs would diminish or resolve the aggregates and thereb...
My accountSign inVolume 155, Issue 4, 7 November 2013, Pages 894-908ArticleInjury-Induced HDAC5 Nuclear Export Is Essential for Axon Regeneration Author links open overlay panelYongcheol Cho 1, Roman Sloutsky 2, Kristen M. Naegle 2, Valeria Cavalli 1Show more Add to Mendeley Share Cite http...
In addition to these two isoforms, nine others were tested for binding using these assays (see below). All exhibited homophilic binding (Table 1). These 11 isoforms included five of the 12 alternative versions for Ig2, five of the 48 alternative versions for Ig3, and seven of the 33 ...
Interestingly, the absence of MCP-1/CCL2 in PMP22tg mice causes a significantly elevated CMAP and a reduced duration in contrast to PMP22tg/MCP-1+/+ at the age of six months. As a functional correlation to CMAPs, we also investigated strengths of distal muscles. For this purpose, we ...