3 PowerPoint slide for Fig. 4 Glossary Calcium wave A localized increase in intracellular calcium concentration that is propagated spatially along the neurite or through the cell body. Growth cone A dynamic motile extension at the tip of a growing neurite that senses molecular cues in the ...
DR6 is broadly expressed by developing neurons, and is required for normal cell body death and axonal pruning both in vivo and after trophic-factor deprivation in vitro. Unlike neuronal cell body apoptosis, which requires caspase 3, we show that axonal degeneration requires caspase 6, which...