Woo SR, Turnis ME, Goldberg MV, Bankoti J, Selby M, Nirschl CJ, et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res. 2012;72:917–27. Article CAS PubMed Google Scholar Escuin-Ordinas H, Elliott MW,...
Ewing’s sarcoma (ES) is a rare and highly aggressive malignant tumor arising from bone and soft tissue. Suffering from intractable or recurrent diseases, the patients’ therapy options are very limited. It is extremely urgent to identify novel potential
Before the experiment, the protein structure was downloaded from the Protein Data Bank (PDB); ligands and water molecules were removed, hydrogen atoms were added, and charges were calculated for both the protein and ligand before saving them in PDBQT format. Using the size of the ligand and ...
VA, USA): normal human liver cells (HL7702); the human HCC lines Hep3B, Huh-7, HCCLM3, SK-HEP1, Li-7, and HepG2; and embryonic kidney HEK293T cells. All cell lines were authenticated by the Cell Bank using short tandem repeat profiling, and a mycoplasma detection kit (Shanghai...
Normal human hepatocytes L-O2 were procured from the Cell Bank of the Chinese Academy of Sciences (Shanghai, China) and grown by using Dulbecco’s Modified Eagle Medium (DMEM) with 10% fetal bovine serum, 100 IU/ml penicillin, and 100 mg/ml streptomycin with 5% CO2 at 37 °C in...
Liu H, Lei C, He Q, Pan Z, Xiao D, Tao Y. Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer. Mol Cancer. 2018;17(1):64. Article Google Scholar Gu S, Rong H, Zhang G, Kang L, Yang M, Guan H. Functional SNP in 3′-UTR microRNA-binding site ...
Ferroptosis, a non-apoptotic form of cell death induced by accumulation of free iron ions and lipid peroxidation, its importance for cancer treatment is gradually being recognized. Research on the anti-cancer mechanism of juglone is accumulating. However
HEK293T cells were obtained from the Cell Bank of the Chinese Academy of Science (Shanghai, China) and were cultured according to the established procedure. The advanced stable cell line of HEK293T Tet-OFF Myc-AURKA and different NRF2 variants were generated by Corues Biotechnology, China. ...
Kusch V, Bornschein G, Loreth D, Bank J, Jordan J, Baur D, et al. Munc13-3 Is Required for the Developmental Localization of Ca(2+) Channels to Active Zones and the Nanopositioning of Ca(v)2.1 Near Release Sensors. Cell Rep. 2018;22:1965–73. Article CAS Google Scholar India Pro...
Normal human hepatocytes L-O2 were procured from the Cell Bank of the Chinese Academy of Sciences (Shanghai, China) and grown by using Dulbecco’s Modified Eagle Medium (DMEM) with 10% fetal bovine serum, 100 IU/ml penicillin, and 100 mg/ml streptomycin with 5% CO2at 37 °C in...