AVA treatment induced nuclear retention of the NPM1 mutant protein (NPMc+) in OCI-AML3 cells and primary AML cells, caused proteasomal degradation of NPMc+ and the nuclear export factor CRM1 and downregulated wt FLT3 protein. In addition, both AVA and its analog induced differentiation of ...
Effects of avrainvillamide on AML cell lines. (a) Structure of avrainvillamide (AVA) and AVA biphenyl analog (BFA). (b) NB4, HL-60, MV4-11, OCI-AML3 and Molm-13 cells were incubated with AVA (10 nM–30 μM) for 24 h, (n=3–7), and proliferation was determined by3...