近日,英国Avacta Therapeutics公司宣布:新药AVA6000在一项针对唾液腺癌患者的1a期临床试验中,展示出积极的疗效,取得了令人鼓舞的无进展生存期(PFS)数据,意味着该药能有效帮助患者控制疾病进展。 无进展生存期(PFS)指从治疗开始到疾病出现进展或...
涉及人类肿瘤细胞系的体外细胞毒性评估显示,与多柔比星相比,AVA6000的细胞毒性低80倍到4,000倍。在对FAP水平较高的肿瘤进行的几项体内疗效研究中,AVA6000以剂量依赖的方式显著减少了肿瘤体积,提高了存活率。在骨肉瘤的PDX模型中,AVA6000能明显缩小肿瘤体积,而多柔比星则无明显效果。 AVA6000临床试验进展 一项1a期...
AVA6000 is a therapeutic product based on proprietary pre|CISION technology which incorporates a substrate that is sensitive to cleavage by FAP. The pre|CISION substrate can be utilized in a drug conjugate linker or to generate chemotherapy prodrugs that are only activated in the tumor ...
“We are delighted to receive orphan drug designation from the FDA for AVA6000, which is a reflection of the high quality of the preclinical data and the potential benefit the pre|CISION platform can bring to cancer patients,” Dr Alastair Smith, chief executive officer of Avacta Group, state...
近日,据Avacta Group plc发布的新闻稿显示,阿霉素(蒽环类化疗药多比柔星)升级版药物AVA6000获美国FDA授予软组织肉瘤孤儿药认定(ODD)[1]。 详情请看下文 阿霉素是一种常用的抗癌药,抗癌范围非常广,在包括白血病、淋巴瘤等血癌,以及肺癌、乳腺癌、卵...
港安健康国际医疗介绍,美国食品和药物管理局(FDA)于近日授予AVA6000孤儿药称号,这是一种改良形式的多柔比星,用于治疗软组织肉瘤患者。 港安健康科普: AVA6000是一种基于pre-CISION专利技术的治疗产品,含有一种对成纤维细胞活化蛋白α(FAP)裂解敏感的底物。2具体而言,该药剂由一个与二肽共价键合的多柔比星分子...
AVA6000 is the first peptide drug conjugate in Avacta’s pipeline and consists of doxorubicin conjugated with Avacta’s proprietary pre|CISION®peptide, that is specifically cleaved by fibroblast activati...
AVA6000 is a novel form of doxorubicin that has been modified with Avacta’s preCISION platform to improve its safety and therapeutic index. Anthracyclines such as doxorubicin, a generic chemotherapy for which the market is expected to grow to $1.38 billion by 2024, are widely used as part of...
“We are very excited by the potential of AVA6000, and the pre|CISION platform more broadly, to deliver ground-breaking and affordable cancer treatments that have the potential to significantly improve patients’ lives.” Subscribe to our e-Newsletters ...
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