These results demonstrate that (i) self peptides derived from human myelin proteins can induce autoreactive CD8+CTLs and (ii) these CD8+T cells produce cytokines thought to be important in mediating demyelinating disease. These studies provide an experimental approach for the assessment of CD8+T-...
These results demonstrate that (i) self peptides derived from human myelin proteins can induce autoreactive CD8+CTLs and (ii) these CD8+T cells produce cytokines thought to be important in mediating demyelinating disease. These studies provide an experimental approach for the assessment of CD8+T-...
Autoreactive CD8+ T cell response in patients with primary biliary cirrhosis: immunological implications from induction through destruction: Hiroto Kita, University of California at Davis, Davis, CA; Zhe-Xiong Lian, Judy Van de Water, Xiao-Song He, Shuji Matsumura, University of California, Davis,...
Despite substantial advances in our understanding of CD4CD25 regulatory T cells, a possible equivalent regulatory subset within the CD8 T cell population has received less attention. We now describe novel human CD8/TCRαβ T cells that have a regulatory phenotype and function. We expanded and ...
Objective To detect and characterize the autoreactive CD8+ T cells to major histocompatibility complex class I chain–related gene A (MICA), a stress‐inducible antigen preferentially expressed on the epithelium and endothelium, in patients with Behet's disease (BD). Methods A candidate for the ...
T cellsRHEUMATOID arthritisVACCINATIONTHERAPEUTICSStudies suggested that experimental autoimmune diseases can effectively be prevented and treated by application of normal autoreactive T cells or autoreactive T cells in an attenuated form. In this study, several aut...
In type 1 diabetes, maturation of activated autoreactive CD8T cells to fully armed effector cytotoxic T lymphocytes (CTL) occurs within the islet. At present the signals required for the maturation process are poorly defined. Cytokines could potentially provide the necessary "third signal" required ...
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. A direct association of islet-autoreactive T cells with 尾 cell destruction in human pancreatic islets from type 1 diabetes (T1D) patients has never been d... Ken,...
Analysis of regulatory CD8 T cells in Qa-1-deficient mice. The mouse protein Qa-1 (HLA-E in humans) is essential for immunological protection and immune regulation. Although Qa-1 has been linked to CD8 T cell-dependent suppression, the physiological relevance of this observation is unclear. ...
In peripheral blood mononuclear cells (PBMCs) from patients with AD, stimulation with α-NAC resulted in proliferation of skin homing CLA+ and CCR4+ T cells compared to CCR4- and CLA− cells [41]. Of the antigen-specific TCC, approximately 60% expressed CD8+ and 40% were CD4+ T cells...