FastingExerciseMononuclear cellsThe concomitant investigation of apoptosis (a regulated cell death) and autophagy (a conserved cell survival mechanism) in immune cells is rare. More detailed knowledge of these two types of self-consumption in circulating lymphocytes and monocytes would be important, ...
It is noted that insulin sensitizers, such as adiponectin, promote the autophagy pathway in skeletal muscle [86]. Exercise, which is known to improve insulin resistance, partly functions through autophagy [186]. In addition, Song et al. showed that dehydroepiandrosterone activates mTORC1 and inhibi...
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature, 481(7382):511–515. https://doi.org/10.1038/nature10758 Article CAS PubMed PubMed Central Google Scholar Henrot P, Blervaque L, Dupin I, et al., 2023. Cellular interplay in skeletal muscle ...
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis Nature, 481 (2012), pp. 511-515, 10.1038/nature10758 View in ScopusGoogle Scholar He et al., 2023 Z. He, H. Xu, C. Li, H. Yang, Y. Mao Intermittent fasting and immunomodulatory effects: a systematic re...
Although exercise and dietary intervention could alleviate NAFLD, some patients may still require drug intervention. Therefore, elucidating the regulatory mechanism of autophagy and developing drugs targeting its activation are vital strategies for treating NAFLD. Omentin-1, a novel adipocytokine synthesized...
Autophagy is essential for the adaptive response to exercise and physiological skeletal muscle functionality. However, the mechanisms leading to the activation of macroautophagy and chaperone-mediated autophagy in human skeletal muscle in response to high-intensity exercise remain elusive. Our findings demon...
Under pathological conditions, autophagy increases are associated with muscle wasting induced by pro-atrophic stimuli, fasting, high-fat diet/insulin resistance, hypoxia, and exercise [60]. Besides, suppression of autophagy has also been proved to be deleterious in some cases. In- deed, autophagic ...
Exercise in a fasted state helps to increase the autophagy signaling mechanism. When you train while fasting, your body senses that it needs more nutrients to produce energy. As muscle cells are damaged during exercise, the body breaks down and rebuilds cellular material. ...
For example, autophagy is needed for exercise-induced improvement of physical performance [12]. Autophagy does not only contribute to anabolic con- sequences of training, but is also pivotal in clearing pro- teins and organelles damaged mechanically (contractions and injuries) and/or metabolically ...
sensitivity to ischemic insults while overexpression of Sestrin2 is protective in old mice [101]. Although there is currently no pharmacological activator of Sestrins, physical exercise increases Sestrin2 protein levels and induces autophagy in the skeletal muscle of old mice [102]. Thus Sestrin2 ...