HLA histocompatibility antigensHISTOCOMPATIBILITY antigensBONFERRONI correctionObjective: While immune checkpoint inhibitors are increasingly used for various cancers, unpredictable immune-related adverse events (irAEs) such as autoimmune encephalitis is life-threatening. Here, we report an association between ...
Although HLA-B27, a human leukocyte antigen class I gene, is currently the strongest genetic risk factor for AS (but not a known risk factor for IBD), several disease-susceptible genes related to type 17 immunity are shared between AS and IBD, such as IL23R, JAK2 and GPR65 [129, 141,...
Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis. J Immunol. 2011;186:2672–80. Article CAS PubMed Google Scholar Kronbichler A, Lee KH, Denicolò S, Choi D, Lee H, Ahn D, et al. Immunopathogenesis of ANCA-associated vasculitis...
Schwimmbeck PL, Yu DTY, Oldstone MBA (1987) Autoantibodies to HLA B27 in the sera of HLA B27 patients with ankylosing spondylitis and Reiter’s syndrome. Molecular mimicry withKlebsiella pneumoniaeas potential mechanism of autoimmune disease. J Exp Med 166:173–181 PubMedCASGoogle Scholar Shoenfe...
Breban M, Hammer RE, Richardson JA, Taurog JD: Transfer of the inflammatory disease of HLA-B27 transgenic rats by bone marrow engraftment. J Exp Med. 1993, 178: 1607-1616. 10.1084/jem.178.5.1607. Article CAS PubMed Google Scholar Nash RA, McSweeney PA, Crofford LJ, Abidi M, Chen CS...
Refolding of the heavy chain of the Class I HLA molecule, HLA-B27, in the absence of β 2m, yields soluble high molecular weight (HMW) oligomers reminiscent of the oligomeric forms of β 2m-free heavy chains (FHCs) of class I HLA antigens observed on cell surfaces. Here we examine the...
30.Benvenga S, Santarpia L, Trimarchi F, Guarneri F. Human thyroid autoantigens and proteins of Yersinia and Borrelia share amino acid sequence homology that includes binding motifs to HLA-DR molecules and T-cell receptor.Thyroid. 2006;16:225-236.[PubMed][Cited in This Article:2] ...
HLA and Autoimmune Digestive Disease: A Clinically Oriented Review for Gastroenterologists OBJECTIVES: The human leukocyte antigen (HLA) system includes genes involved in graft-vs-host rejection and in immune response. The discovery that HLAs are... A Cassinotti,S Birindelli,M Clerici,... - 《...
AS associates strongly with particular HLA-B27 subtypes12,13. While the search for arthritogenic peptides that these class I HLA antigens putatively present is underway, a recent study found no qualitative differences in peptide binding preferences among HLA-B27 subtypes that associate with AS, ver...
V. CD20 (pan-B cell) antigen is expressed at a low level on a subpopulation of human T lymphocytes. Cytometry 14, 196–204 (1993). Article CAS PubMed Google Scholar Eggleton, P. et al. Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher ...