Background: Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy usually presents as meningoencephalomyelitis. Many patients developed flu-like symptoms preceding the neurologic symptoms. Reversible lesion in the splenium of the corpus callosum (SCC) is a clinical and radiological syndrome ...
Glial fibrillary acidic protein (GFAP) autoimmune astrocytopathy is characterized by GFAP autoantibody positive encephalitis, meningoencephalitis or meningoencephalomyelitis. The initial clinical presentation may be similar to central nervous system infections making early diagnosis challenging. Case presentation...
(e, insert); f: dystrophic axons at the lesion edge show accumulation of amyloid precursor protein (APP) as a sign of disturbed axonal transport; g, h: Profound protoplasmic astrocytic gliosis is seen in sections stained for glial fibrillary acidic protein (GFAP); some of the astrocytes ...
Cerebrospinal fluid interleukin-6 and glial fibrillary acidic protein levels are increased during initial neuromyelitis optica attacks. Clin. Chim. Acta 421, 181–183 (2013). Article CAS PubMed Google Scholar Korn, T. et al. IL-6 controls Th17 immunity in vivo by inhibiting the conversion of...
31. Kunchok A, Zekeridou A, McKeon A. Autoimmune glial fibrillary acidic protein astrocytopathy.Curr Opin Neurol.2019;32(3):452-458. 32. Fang B, McKeon A, Hinson SR, et al. Autoimmune glial fibrillary acidic protein astrocytopathy: a novel meningoencephalomyelitis.JAMA Neurol.2016;73(...
Matrix Metalloproteinase 9 (MMP9) is involved in blood-brain barrier (BBB) disruption in active multiple sclerosis [32] whereas glial fibrillary acidic protein (GFAP) may have prognostic value in multiple sclerosis [33]. False associations (cf. table 7, column 6) are mainly based on false ...
sections, staining for various cell-type markers revealed that the dNP2-dTomato protein signal was significantly co-localized with neurons (Neuronal Nuclei (NeuN)-positive cells), astrocytes (Glial fibrillary acidic protein (GFAP)-positive cells) and microglial cells (Ionized calcium binding adaptor ...
Expression of HO-1, the monocyte differentiation antigen ED1, the T-cell differentiation antigen W3/13 and the glial fibrillary acidic protein (GFAP) were studied by immunohistology. Similar results on distribution of HO-1+ cells were obtained in EAE and EAN. In general, HO-1+ cells were ...
glial fibrillary acidic protein GL: granular layer GluR: ionotropic glutamate receptors GluRδ2: glutamate receptor delta 2 GRAF1: GTPase regulator associated with focal adhesion kinase 1 HEK: human embryonic kidney IB: immunoblot assay ICC:
Next to this pronounced microgliosis, we also observed a significant increase in the numbers of glial fibrillary acidic protein (GFAP)-positive astrocytes in LEWzizi rats (Additional file 1: Figure S3a, b). Moreover, we noticed an abnormally increased, age-related iron accumulation in the ...