3Theories on the pathogenesis of autoimmune diseases [7] There are several theories as to the cause(s) of the idiosyncratic autoimmune responses that we will examine. But whatever the cause(s), the response has created an entirely separate disease category referred to as “autoimmune disease.”...
Therefore, long COVID is a huge challenge that deserves our attention. The long-term complications of COVID-19, especially the occurrence of autoimmune diseases, are becoming a major focus of research as the global disease burden increases. Several new-onset autoimmune illnesses, including systemic...
The prevalence of autoimmune diseases (ADs) worldwide has rapidly increased over the past few decades. Thus, in addition to the classical risk factors for ADs, such as genetic polymorphisms, infections and smoking, environmental triggers have been considered. Recent sequencing-based approaches have ...
A role for the (gut)microbiome: Accumulating evidence suggests that an altered microbiome might be a key event in the development of autoimmunity in general.72,73HLA haplotypes predisposing to autoimmune diseases are associated with distinct microbiome diversity and core microbiome.74Recently, changes ...
Neutrophils play fundamental roles in innate immune response, shape adaptive immunity, and are a potentially causal cell type underpinning genetic associations with immune system traits and diseases. Here, we profile the binding of myeloid master regulat
(AEP) diet serves multiple purposes. It helps heal leaky gut, identify immune-reactive foods, and calm the immune system to manage autoimmune diseases like Hashimoto’s. Around ten years ago, bloggers rebranded this diet as the “autoimmune paleo,” or AIP, diet. However, I prefer the long...
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Autoimmune diseases develop due to self-tolerance failure in recognizing self and non-self-antigens. Several factors play a role in inducing autoimmunity, including genetic and environmental elements. Several studies demonstrated the causative role of vi
Autoimmune diseases (AID) affect about 5% of the population. Current systemic therapies are rarely curative for those patients with the most severe, life-threatening forms of AID. During the past 15 years, based on the experience from experimental models and early clinical trials, hematopoietic stem...
The dietary habits of humans have changed dramatically in the last few decades, notably in industrialized western countries and in urban societies. Parallel to these changes, there has been a considerable increase in autoimmune diseases that include multiple sclerosis (MS)1,2. As opposed to people...