Why is autoimmune disease more common in females? More Women Than Men Have Autoimmune Diseases Genetics: Thelarger number of genes originating from the X chromosome(women have two while men have one) creates a far greater possibility of a larger number of mutations occurring, putting women at a...
and in the UK, 1 in 10 people have an autoimmune disease [1,2,3]. The majority of autoimmune diseases are more common in women than men [4] and are a leading cause of death in women between the age of 65 and 75 in the US and UK [5,6]. Although the aetiology of autoimmunity...
and in line with this,humoral immunityis greater in females.95As a consequence, skin autoimmune diseases mediated by autoantibodies are usually far more common in females. In contrast, autoimmune diseases of equal distribution in male and females, such as chronicplaque psoriasis,96are often T-cell...
This is one of the main causes of AIE. It is more common in young women (80%) and children[4]. Anti-NMDAR antibodies are associated with ovarian teratoma in young females, whereas ovarian carcinoma predominates in the elderly[4]. Other tumors described in anti-NMDAR AIE are breast cancer...
Before the diagnosis of a mood disorder, a total of 29 194 patients (31.9%) were diagnosed as having one or more infections (19 424 females and 9770 males), 4195 (4.6%) were diagnosed as having one or more autoimmune diseases (2692 females and 1503 males), and 2113 (2.3%) were...
"VGLL3 appears to regulate immune response genes that have been implicated as important toautoimmune diseasesthat are more common in women, but that don't appear to be regulated by sex hormones," says Johann Gudjonsson, M.D., Ph.D., who led the research team and is a professor of derma...
METHODSThirty-five suspected MG patients (25 females and 10 males, ranging from 18 to 83 years) were clinically evaluatedat the Referral Center of Neuromuscolar and Rare Neurological Diseases, at San Filippo Neri Hospital in Rome,according to the International Consensus Guidance for Management of ...
in the study had at least one concomi-tant EHA disease.Sjgren's syndrome(n=140,14.2%)was the most frequent one,followed by rheuma-toid arthritis(RA)(n=56,5.7%)and Hashimoto's thyroiditis(n=45,4.6%).Patients with EHA dis-eases were more common in females(P<0.001)and in those with...
Autoimmunerheumatic diseases(ARDs) are a group of systemic autoimmune disorders that mainly affect joint, bones and soft tissues and are associated with substantial morbidity and mortality[1]. These diseases are characterized by systemic inflammation and share commonclinical features, including chronic pain...
(Roseet al., 1971;Vladutiu and Rose, 1972). Although it is the last animal model to be described (Rose, 1976), it has proven the most useful in obtaining an understanding of thegenetic and T-cell regulation of autoimmune diseases because of parallel advances in our knowledge of mouse ...