Review Article Published: 15 December 2020 B cell depletion therapies in autoimmune disease: advances and mechanistic insights Dennis S. W. Lee, Olga L. Rojas & Jennifer L. Gommerman Nature Reviews Drug Discovery volume 20, pages 179–199 (2021)Cite this article 129k Accesses 80 Altmetric...
21-hydroxylase, patients have a period of compensated or preclinical disease, characterized by elevations in adrenocortocotropic hormone and renin, before overt, symptomatic adrenal failure develops
Journal of Immunology, Nature Immunology, Annual Review of Immunology, Journal of Autoimmunity, Open Journal of Rheumatology and Autoimmune Diseases. Autoimmune markers Autoimmune diseases are followed by disease hence autoantibodies can acts as a marker for the disease. If an antibody serve as a disea...
Here, we review the current understanding of the genetics of autoimmune Addison disease and its position in the wider field of autoimmune disorders. The mechanisms that could underlie the effects on the adrenal cortex are also discussed.doi:10.1038/s41574-022-00653-yEllen C. Ryrvik...
Treatment of rheumatoid arthritis-associated interstitial lung disease: a perspective review Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting 0.5-1% of the worldwide population. Whilst predominantly causing chronic pain and infl... K Iqbal,C Kelly - 《Therapeutic Advances in Musculos...
Given the similar features of many of the organ-specific autoimmune disorders, it is likely that if immunotherapeutic modalities are successful in one disease, they may be of benefit in related disorders. With respect to the significant morbidity and potential mortality of the disease, the main ...
B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets B7-H3 is a cell surface molecule in the immunoglobulin superfamily that is frequently upregulated in response to autoantigens and pathogens during host T cell immune responses. Ho...
Therefore, in this review we discuss the relevance of PD-1 function in NK and T cells in autoimmunity, and demonstrate similarities and differences of its function in autoimmune diseases and cancer. Thus, PD-1 can be targeted to treat each disease entity accordingly. In cancer, the function ...
M. The contribution of PTPN22 to rheumatic disease. Arthritis Rheumatol. 71, 486–495 (2019). Article CAS PubMed PubMed Central Google Scholar Tizaoui, K. et al. The role of PTPN22 in the pathogenesis of autoimmune diseases: a comprehensive review. Semin. Arthritis Rheum. 51, 513–522 ...
et al. Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nature Med. 11, 138–145 (2005). Article CAS PubMed Google Scholar Yumoto, H. et al. Sensitization of human aortic endothelial cells to lipopolysaccharide via regulation of Toll-like receptor 4...