Autoimmune diseases are defined as an abnormal response of B cells and/or T cells towards endogenous antigens, which in turn leads to self-directed immunity and eventually presents as either localized tissue damage or as a systemic disease. ...
Antiinflammatory agents; autoimmune disease; anticancer agents; antitumor agents; wound healing agentsdoi:US20020068320 A1The present invention relates to novel human serine protease polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided ...
Curcumin is a polyphenolic compound isolated from the rhizome of the plant Curcuma longa that has traditionally been used for pain and wound-healing. Recent studies have shown that curcumin ameliorates multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease in human or animal...
In systemic lupus erythematosus, loss of immune tolerance, autoantibody production and immune complex deposition are required but not sufficient for organ damage1. How inflammatory signals are initiated and amplified in the setting of autoimmunity remains elusive. Here we set out to dissect layers and ...
of diseases of the last few hundred years have been reduced or eliminated with the tremendous progress in medical research. In their place however, other health hurdles have exploded, like autoimmune disease, metabolic disease, blood sugar issues, food sensitivities, fatigue, brain fog – and more...
Autoimmune hepatitis (AIH) is an immune-mediated liver disease that currently faces limited treatment options. In its advanced stages, AIH can progress to ... X Wang - 《Biomolecules》 被引量: 0发表: 2024年 Exosome-mediated PROTAC delivery for treatment of RNA viral infections and zoonosis Add...
Autoimmune hepatitis (AIH) is a severe liver disease that affects children and adults worldwide. The diagnosis of AIH relies on increased serum transaminase and immunoglobulin G levels, presence of autoantibodies and interface hepatitis on liver histolog
Using high-resolution single-cell profiling of kidney immune and parenchymal cells, in combination with antibody blockade and genetic deficiency, we show that tissue-resident NKp46+ innate lymphoid cells (ILCs) are crucial signal amplifiers of disease-associated macrophage expansion and epithelial cell ...
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease in which insulin-producing beta cells of the pancreatic islets of Langerhans are destroyed. T... Franoise Homo-Delarche - 《Ilar Journal》 被引量: 44发表: 2004年 加载更多来源...
A. GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential. Expert Rev. Clin. Immunol. 11, 457–465 (2015). CAS PubMed Google Scholar Wicks, I. P. & Roberts, A. W. Targeting GM-CSF in inflammatory diseases. Nat. Rev. Rheumatol. 12, ...