This notion is supported by the lack of an effect by either the Rac-effector or Rac-insert region mutants on NOX2 autoactivation. The kauto values of Rac and NOX2 estimated within this study suggest that the rate of Rac and NOX2 autoactivation is sufficiently fast. In cells, Rac and ...
MET has gained interest as a therapeutic target for a number of malignancies because of its involvement in tumorigenesis, invasion and metastasis. At present, a number of inhibitors, both antibodies against MET or its ligand hepatocyte growth factor, and small molecule MET tyrosine kinase inhibitors ...