Autism spectrum disorders (ASDs) are a group of conditions characterized by impairments in communication and reciprocal social interaction, and the presence of restricted and repetitive behaviors. The spectrum of autistic features is variable, with severity of symptoms ranging from mild to severe, someti...
consistent, direct, and strong association without publication bias. For systematic reviews, we narratively summarized the authors’ conclusion in a separate table (because quantitative assessment was not possible). For each potential risk factor, the latest systematic review or meta-analysis was...
ASH1L, a histone methyltransferase, is identified as a top-ranking risk factor for autism spectrum disorder (ASD), however, little is known about the biological mechanisms underlying the link ofASH1Lhaploinsufficiency to ASD. Here we show that ASH1L expression and H3K4me3 level are significantly de...
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Although elevation of blood and platelet serotonin has been documented in autism, genetic analyses of serotonin transporter gene have given conflicting res... Rafiqun,Nabi,Fatema,... - 《American Journal of Medical Genetics Part B Neuropsychiatric Genetics》 被引量: 146发表: 2004年 ...
Autism Res 1: 275–283. Article PubMed PubMed Central Google Scholar Heuer L, Braunschweig D, Ashwood P, Van de Water J, Campbell DB (2011). Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression. Transl Psychiatry ...
Predicting the functional impact of protein mutations: application to cancer genomics. Nucleic Acids Res. 2011;39(17):37–43. Article Google Scholar Schwarz JM, Rödelsperger C, Schuelke M, Seelow D. MutationTaster evaluates disease-causing potential of sequence alterations. Nat Methods. 2010;...
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(Frith,2003). As autistic characteristics are presented as social communication, restricted, repetitive behaviour domains and hypo- or hyper-reactivity to sensory stimuli, the diagnosis is likely to impact individuals differently (Charman,2015). Those who are diagnosed as having autism may face ...