目的:万古霉素(VAN)药动学/药效学(PK/PD,即AUC_(0-24)/MIC)靶值为≥400,成人患者实现该靶值VAN谷浓度(C_(min))需达到15-20 mg/L,新生儿中需达到7-11mg/L.关于在中国儿科患者中,能够使VAN实现该靶值对应的C_(min)尚没有研究.本研究的目的是通过建立VAN群体药代动力学模型,探究VAN C_(min)与PK/PD...
Association between the AUC0-24/MIC ratio of vancomycin and its clinical effectiveness: a systematic review and meta-analysis. PLoS One 2016; 11: e0146224.Association between the AUC0-24/MIC ratio of vancomycin and its clinical effectiveness:a systematic review and meta-analysis. MEN P,LI H ...
Results: Peak/MIC was most predictive of early bacterial kill, whereas T > MIC was significantly associated with final bacterial counts at 24 h. Antibacterial effects were bacteriostatic when T > MIC was 48% and bactericidal when values exceeded 55%. AUC0–t/MIC was strongly associated with ...
mg/L and AUC 0‐24 /MIC ≥400 in 2.0‐ and 1.6‐fold as many children compared to a dose of 10?mg/kg every 6?hours, respectively. Vancomycin C min values of 5.0‐12.9?mg/L were strongly predictive of achieving AUC 0‐24 /MIC ≥400, and rational dosing regimens of 10‐15?mg/kg...
Methods: In dose escalation studies, single doses with peak concentrations equivalent to 1 ×, 2 ×, 4 ×, 8 ×, 16 × and 32 × MIC against two isolates of S. pneumoniae were studied over 24 h. Traditional pharmacodynamic indices, including peak concentration divided by MIC (peak/MIC),...