The latest consensus recommends using the ratio between the area under the curve over 24 h (AUC 0–24 ) and minimal inhibitory concentration (MIC) as the therapeutic target for vancomycin in clinical practice, with a Bayesian approach and population pharmacokinetic (popPK) model being particularly...
0-24 /MIC ≥400 in 2.0- and 1.6-fold as many children compared to a dose of 10mg/kg every 6hours, respectively. Vancomycin Cmin values of 5.0-12.9mg/L were strongly predictive of achieving AUC0-24 /MIC ≥400, and rational dosing regimens of 10-15mg/kg q6h were required in ...
mg/L and AUC 0‐24 /MIC ≥400 in 2.0‐ and 1.6‐fold as many children compared to a dose of 10?mg/kg every 6?hours, respectively. Vancomycin C min values of 5.0‐12.9?mg/L were strongly predictive of achieving AUC 0‐24 /MIC ≥400, and rational dosing regimens of 10‐15?mg/kg...
Association between the AUC0-24/MIC ratio of vancomycin and its clinical effectiveness: a systematic review and meta-analysis. PLoS One. 2016; 11(1):e0146224.Men P, Li H-B, Zhai S-D, Zhao R-S. Association between the AUC0- 24/MIC ratio of vancomycin and its clinical effectiveness: ...
Methods: In dose escalation studies, single doses with peak concentrations equivalent to 1 ×, 2 ×, 4 ×, 8 ×, 16 × and 32 × MIC against two isolates of S. pneumoniae were studied over 24 h. Traditional pharmacodynamic indices, including peak concentration divided by MIC (peak/MIC),...