Estimation of AUC from 0 to infinity in serial sacrifice designs. J Pharmacokinet Pharmacodyn. 2005;32 (5-6):757-66.Wolfsegger MJ, Jaki T (2005) Estimation of AUC from 0 to infinity in serial sacrifice designs. J Pharmacokinet Pharmacodyn 32(5–6):757–766 : 10.1007/s10928-...
Fifteen biologics license applications (BLAs) were included to determine the concordance and geometric percent coefficient of variation (%CV) between tAUCs evaluated on days7, 14, 21, and 28 and AUC evaluated to infinity (AUC0–inf). Concordance is established if the tAUCs are comparable with ...
From analysis of the experimental data, total AUC covering from time zero to infinity can be estimated. Calculation of estimated plasma concentration can also be made for any time point. Instead of using T1/2 as an index for expressing how fast a drug is cleared, TAUC90%, which is the ...
(1..Infinity) => 1 minimal_bids = { (0...5_000) => 100, (5_000...20_000) => 500, (20_000...100_000) => 1_000, (100_000...500_000) => 5_000, (500_000...1_000_000) => 10_000, (1_000_000...2_000_000) => 50_000, (2_000_000..) => 100_000 } ...
AUC extrapolated to infinity (AUC0–∞) after the first dose was estimated using the three methods, whereas reference AUC (AUCref) was calculated using the linear-trapezoidal method at steady state after repeated doses. The ratio of AUC0–∞: AUCref and % bias were selected as the ...