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In humans, the family comprises 21 members that have been grouped into subfamilies: Cdc42-like (Cdc42, TC10/RhoQ, TCL/RhoJ, Chp/Wrch-2/RhoV, Wrch-1/RhoU), Rac-like (Rac1–3, RhoG), Rho-like (RhoA–C), Rnd (Rnd1–2, Rnd3/RhoE), RhoD (RhoD and Rif/RhoF), RhoH/...