ATX-101 is a novel cell-penetrating APIM-containing peptide, shown to target PCNA and block PCNA-protein interactions [10]. ATX-101 has anti-cancer activity as a single agent in multiple cancer cell lines and cancer models and, in addition, potentiates the activity of multiple other anti-can...
Correction: Gravina et al. ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma. Cancers 2022, 14 , 289doi:10.3390/cancers16162897GLIOMASANTINEOPLASTIC agentsDRUG efficacy...
Simple Summary: PCNA is an interesting target for cancertreatment due to its essential activities in DNA replication and repair and its recently discovered regulatory roles in cellular signaling. Here, we demonstrate that ATX-101, a peptide targeting PCNA, has antitumor effects as a single agent an...
ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma Here, we show that a cell-penetrating peptide containing the AlkB homolog 2 PCNA-interacting motif (APIM), ATX-101, has antitumor activity in a panel... ...
ATX-101, a cell-penetrating APIM-peptide, targets PCNA.Rebekka, MüllerKristine, MisundToril, HolienSiri, BachkeKarin, M. GilljamThea, K. VåtsveenTorstein, B. RøEmanuele, BellacchioAnders, SundanMarit, Otterlei
Correction: Gravina et al. ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma. Cancers 2022, 14, 289doi:10.3390/cancers16162897In the original publication [...]Claudio Festuccia...
PCNA may potentially interact with more than 600 proteins through either of the two PCNA-interacting motifs: the PCNA-interacting peptide (PIP)-box and APIM [34,35]. The PIP-box and APIM have overlapping interaction sites on PCNA [32,36], but while most of the essential replicative ...
Correction: Gravina G.L. et al. ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma. Cancers 2022, 14, 289doi:10.3390/cancers16162897In the original publication [...]Claudio Festuccia...
Objectives: To examine the regulatory role of PCNA in MM, we have targeted PCNA with the experimental drug ATX-101 in three commercial cell lines (JJN3, RPMI 1660, AMO) and seven in-house patient-derived cell lines with a more primary cell-like phenotype (TK9, 10, 12, 13, 14, 16 ...