ArticleOpen access29 August 2024 Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology ArticleOpen access06 October 2022 A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregat...
22. The mRNA cancer vaccine of any one of claims 1-21, wherein the mRNA is formulated in a lipid nanoparticle carrier. 23. The mRNA cancer vaccine of claim 22, wherein the lipid nanoparticle carrier comprises a molar ratio of about 20-60% cationic lipid:5-25% non-cationic lipid:25-55...
The constitutive knock-out of Atxn2 in mice leads to progressive weight gain with excessive storage of lipid droplets and glycogen in the liver, elevated cholesterol and other lipids in the blood, beta-cell hyperplasia in the pancreas with hyperinsulinemia and insulin resistance, increased ganglioside...