ATTR-CM is a disease that makes the heart stiff and weak. It happens when faulty proteins build up, which makes it harder to pump blood throughout the body. This can lead to heart failure if left untreated. Your doctor may call it transthyretin (TTR) amyloid cardiomyopathy. Here’s what...
2025年03月27日(加州帕罗奥图)BridgeBio Pharma, Inc.宣布,日本厚生劳动省已批准Beyonttra(acoramidis)用于治疗患有转甲状腺素蛋白介导的淀粉样心肌病 (ATTR-CM) 的成年人。 日本的批准是基于 Alexion、AstraZeneca Rare Disease 在日本开展的一项 3 期开放标签单臂研究的积极结果,以及全球 ATTRibute-CM 3 期研究...
在TTR相关疾病的研究中，研究最多的是TTR相关淀粉样变性病，如转甲状腺素蛋白淀粉样变性心肌病（Transthyretin Cardiac Amyloidosis Myocardiopathy，ATTR-CM） [15]、转甲状腺素蛋白淀粉样变性多发性神经病（Transthyretin Amyloid Polyneuropathy，ATTR-PN） [16]，以及阿尔兹海默症（Alzheimer's Disease，AD） [17]。TTR...
What Is TTR? TTR Destabilization: The Source of ATTR‑CM Destabilization of the transthyretin (TTR) protein, also known as prealbumin, leads to low levels of serum TTR and has been correlated with earlier disease onset and poor clinical outcomes in people with transthyretin amyloid cardiomyopathy...
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Having a new first line treatment option which provides excellent TTR stabilization and improves outcomes in this disease gives patients more options,” said Martha Grogan, MD, of the Mayo Clinic. “Encouraging data suggests Attruby reduces all-cause mortality and cardiovascular hospitalization as ...
In addition, the true prevalence of the disease is unknown because many cases go undiagnosed. Patients with ATTR-CM are also often misdiagnosed with more common conditions. Are you up to date on your understanding of ATTR-CM presentation and diagnosis? Test your knowledge with a quick quiz. ...
Attruby is a prescription medicine used to treat adults with a disease that affects the heart muscle called cardiomyopathy of wild-type or variant transthyretin-mediated amyloidosis (ATTR-CM), to reduce death and hospitalization related to heart problems. It is not known if Attruby is safe and...
Attruby is a prescription medicine used to treat adults with a disease that affects the heart muscle called cardiomyopathy of wild-type or variant transthyretin-mediated amyloidosis (ATTR-CM), to reduce death and hospitalization related to heart problems. It is not known if Attruby is safe and...
In ATTR-CM, quantitative cardiac 99mTc-DPD uptake correlates with myocardial amyloid load, longitudinal cardiac function, cardiac biomarkers, exercise capacity, and disease stage. DPD quantification may provide a valuable tool for quantifying and monitoring cardiac disease burden in affected individuals....