FlavivirusFractional dosingInternational health regulationsVaccineYellow feverYellow fever (YF) is regarded as the original hemorrhagic fever and has been a major public health problem for at least 250years. A very effective live attenuated vaccine, strain 17D, was developed in the 1930s and this ...
The invention relates to a live-attenuated yellow fever virus strain adapted to grow on Vero cells from a parent yellow fever virus 17D substrain that is not adapted to grow on Vero cells, wherein said live-attenuated yellow fever virus strain is less neurovirulent than said parent yellow ...
The yellow fever virus vaccine, a live-attenuated strain called 17D, is probably the safest and most effective vaccine ever generated. 对于活疫苗的安全性也有一些例外,如黄热病毒疫苗,虽然是一种减毒病毒株(称为17D),却可能是目前所有疫苗中最安全和最有效的。 WikiMatrix Effect of breastfeeding ...
Zika virus (ZIKV) is an emerging mosquito-borne pathogen representing a global health concern. It has been linked to fetal microcephaly and other birth defects and neurological disorders in adults. Sanofi Pasteur has engaged in the development of an inactivated ZIKV vaccine, as well as a live ch...
The yellow fever virus vaccine, a live-attenuated strain called 17D, is probably the safest and most effective vaccine ever generated. 对于活疫苗的安全性也有一些例外,如黄热病毒疫苗,虽然是一种减毒病毒株(称为17D),却可能是目前所有疫苗中最安全和最有效的。 WikiMatrix To expedite the approval...
CYD-DENV (Dengvaxia®, developed as a chimeric virus with yellow fever vaccine strain YF-17D) was first approved in Mexico in 2015 [1] and has since been approved in 20 countries worldwide [11]. However, post-marketing surveillance (Phase 3 follow-up) has shown that the vaccination of...
Live-attenuated vaccines (LAVs) represent a promising approach for flavivirus vaccine development. In the present study, we demonstrated a method for generating flavivirus LAVs based on breaking spatially and temporally regulated C-prM cleavage to distur
In this study, NDV LaSota vaccine strain that has been widely used for control and prevention of Newcastle disease in chicken was rescued from genome cDNA clone by reverse genetic. 一、新城疫病毒LaSota疫苗株反向遗传操作系统建立 新城疫病毒(Newcastle disease virus,NDV)为不分节段单股负链RNA病毒,...
In order to establish a suitable KFD mouse model for vaccine efficacy testing, we infected two commonly used immunocompetent inbred (BALB/c and C57BL/6) and one immunocompetent outbred mouse strain (CD1) by the intraperitoneal (IP) route. Groups of 10 female mice were infected with either 10...
The invention relates to live attenuated VDV2 (VERO-Derived Vaccine Dengue serotype 2) strains which have been derived from the wild-type dengue-2 strain 16681 by passaging on PDK a