Exciting recent developments suggest that \\{ATRX\\} plays a variety of key roles at tandem repeat sequences within the genome, including the deposition of a histone variant, prevention of replication fork stalling, and the suppression of a homologous recombination-based pathway of telomere ...
ATRX localizes to GC-rich sequences to regulate gene expression of certain loci [17,62]. Previous work has characterized ATRX regulation of the α-globin locus and the NME4 gene, both of which contain a variable number tandem repeat (VNTR). Interestingly, the longer the VNTR, the higher ...
Many of the intergenic sites were composed of simple tandem repeat DNA sequences particularly those with a high GC content and prone to form a secondary DNA structure known as a G-quadruplex (G4 DNA) [29]. Some of the key sequences predicted to form G4 DNA are telomeric repeats and ...
Since ATRX is known to bind tandem repeat DNA sequences, we tested whether the regions that gain ATRXΔRBR were enriched for specific DNA motifs. We compared regions that gain ATRX to those that lose it upon RBR deletion (Fig. 4b, gray and green areas) and found that ATRXΔRBR bound to...
One model for how ATRX targets H3.3 incorporation in vivo is based on the finding that ATRX binds G-rich repeat sequences, which are prevalent in telomeres [34]. These repeat sequences have a predisposition for forming G-quadruplex (G4) structures, and ATRX preferentially binds t...