However, their interaction effects were not significant on the expression level of the Atrogin-1 gene.Madani, FatemehKazemzadeh, YaserJournal of Rafsanjan University of Medical Sciences
3 . 0 kb 的 片段与 pcDNA 3 . 1 空载体的大小一致 , 1100 bp 的 片段与 Atrogin21 cDNA 的大小一致。(2) DNA 测 序的结果 上海 Sangon 公司双向测序结果显示重组 载体所含 Atrogin21cDNA 之碱基序列与 Genen2 bank 上完全一致。 2 . 3 目的蛋白在 293 T 细胞中的表达 大量抽提 重组载体 , 转染...
Our in vitro experiments (Figs 2~4) demonstrated that an AHR inhibitor significantly suppressed the IS-induced production of ROS, inflammatory cytokine expression and atrophy-related gene (atrogin-1 and myostatin) expression. In addition, AHR-siRNA also suppressed IS-induced atrogin-1 and ...
Myostatin-induced skeletal muscle atrophy results in the downregulation of myogenic gene expression (Lokireddy et al., 2012b). Overexpression of myostatin in postnatal skeletal muscle reduced the expression of several myogenic structural genes, including Myh and desmin. Furthermore, myostatin-mediated ...
摘要: PROBLEM TO BE SOLVED: To provide a new, safe, and highly effective substance capable of controlling atrogin-1 gene.SOLUTION: Provided is an expression suppressing medicine for atrogin-1 gene, which containins oyster.收藏 引用 批量引用 报错 分享 ...
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Thus, inhibition of HDAC1 prevented a HS-mediated increase in MAFbx and ubiquitin expression, but did not affect MuRF-1 gene expression.doi:10.1038/s41598-019-46753-0Ekaterina P. MochalovaSvetlana P. BelovaTimur M. MirzoevBoris S. Shenkman...
摘要: Studies the properties of atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Cloning and structure of the atrogin-1 gene; Primary function of muscle proteins; Expression of atrogin-1 in atrophying muscles....
Butler-Browne, The mitotic clock in skeletal muscle regeneration, disease and cell mediated gene therapy. Acta Physiol. Scand. 184(1), 3–15 (2005). doi:10.1111/j.1365-201X.2005.01417.x Article PubMed CAS Google Scholar R.M. Reznick, H. Zong, J. Li, K. Morino, I.K. Moore, ...
IGF-I and TNF-伪 changed atrogin-1 gene expression in opposite directions at 2h, causing decreases and increases in its mRNA, respectively. TNF subsequently decreased mRNA levels starting at 4h and reaching 50% of controls at 8, 12 and 24h. Protein content of the cells was mildly and ...