AAA+ domain containing 2, ANCCA, ATPase family, meta-analysis, PRO2000, prognostic value, survivalBackground:ATPase family, AAA+ domain containing 2 (ATAD2) is also known as AAA+ nuclear coregulator cancer-associated protein or PRO2000. ATAD2 has been reported as a prognostic factor in ...
ATAD3, a vital membrane-bound mitochondrial ATPase involved in tumor progressionATAD3 (ATPase family AAA domain-containing protein 3) is a mitochondrial membrane bound ATPase whose function has not yet been discovered but its role is ... S Li,D Rousseau - 《Medecine Sciences M/s》 被引量: ...
In order to investigate the clinical value of ATPase family AAA domain containing 3A (), a potential anti-apoptotic factor in (PCa), immunohistochemistry was used to measure expression in pathological specimens from 86 Chinese patients and in 183 tissue-array samples from American patients. The eff...
AAAATPase(ATPases Associated with diverse cellular Activities) A distinct family of ATPases characterized by the presence of highly conserved domains in their primary sequence, hexameric structure, and protein unfolding activity. ATPase Type ofenzymethathydrolyzesATP and uses the energy released to driv...
Analysis of the -lacking genome reveals that it possesses a gene, IPR003593 AAA core, which codes a 56 kDa containing one AAA domain. Phylogenetic classification made by CLANS, positioned this sequence into the ARC divergent branch of the AAA family of . N-terminal analysis of the sequence ...
Other members of the type II AAA-ATPase family, for example Cdc48/p97 or Rix7, contain only a single N-terminal domain, which is nevertheless structurally related to the N-terminal domains of Pex1/Pex6 and known to mediate a plethora of interactions with co-factors and adaptor proteins36...
In addition, our results show that benzo-diazaborine binds to the ATPase sites of both D1 and D2 domains, and locks the hexamer in a more symmetrical conformation. As one of the highly potent inhibitors in the diazaborine family compounds against bacteria45, our data thus provide critical ...
Structure and Function of the N-terminal Nucleolin Binding Domain of Nuclear Valosin-containing Protein-like 2 (NVL2) Harboring a Nucleolar Localization Si... The N-terminal regions of AAA-ATPases (ATPase associated with various cellular activities) often contain a domain that defines the distinct...
Valosin‐containing protein (VCP)/p97/Cdc48 is an AAA + ATPase associated with many ubiquitin-dependent cellular pathways that are central to protein quality control. VCP binds various cofactors, which determine pathway selectivity and substrate processing. Here, we used co-immunoprecipitation and...
We were able to collect useful images from the grid areas containing very thin ice (Fig. 1a). Using 75,909 overlapping segments from 602 micrographs, we helically reconstructed TorsinA at ~4.4 Å resolution (Fig. 1; Supplementary Figs 2, 3, and Table 1). The resulting structure showed...