Tightening of the ATP-binding sites induces the opening of P2X receptor channels . EMBO J 31 : 2134 – 2143 .Jiang R., Taly A., Lemoine D., Martz A., Cunrath O., Grutter T. (2012). Tightening of the ATP-binding sites induces the opening of P2X receptor channels . EMBO J. 31...
VASCULAR ENDOTHELIAL MYOSTATIN MUTANT THAT MUTATES AT ATP BINDING SITESVASCULAR ENDOTHELIAL MYOSTATIN MUTANT THAT MUTATES AT ATP BINDING SITESThe present invention discloses a new anti-tumor medicament comprising a mutant of endostatin. The mutant comprises a mutation in the ATP-binding site of endosta...
Accurate identification of adenosine triphosphate (ATP) binding sites is crucial for understanding cellular functions and advancing drug discovery, particularly in targeting kinases for cancer treatment. Existing methods face significant challenges due to their reliance on time-consuming precomputed features ...
These experiments, although confirming that both the ATP-binding sites were located intracellularly, did not allow definitive conclusions to be formed on the exact number and topology of individual membrane spanners in the two symmetrical halves of the protein. In addition, the recent identification ...
The interaction between adenylate kinase and ATP serves as a good model system for our top-down MS/MS methodology because the ATP-binding sites of AK have long been investigated by NMR [26, 27], X-ray crystallography [28, 29, 30], and photoactive labeling [31]. AK (ATP:AMP ...
thesesequencesmaycom municatetheeffectsofATP-bindingto channel function by tuning conformational motions within the neighboring cytoplasmic regulatory domains. Two other labeled fragments lack ATP-binding consensus motifs and may form non-canonical ATP-binding sites. Based on domain topology in the 3D ...
The Q-loop motif contains a conserved glutamine residue at its N-terminus, which is important for cross- talk between ATP-binding sites of the TMDs, as well as dimerization (D-loop) that couples ATP hydrolysis to substrate transport (Locher, 2016; Akhtar and Turner, 2022). These sequence ...
Adenosine-5′-triphosphate (ATP) is one of multifunctional nucleotides and plays an important role in cell biology as a coenzyme interacting with proteins. Revealing the binding sites between protein and ATP is significantly important to understand the f
Even though PAN has six identical subunits, it is known to have two high-affinity ATP- binding sites, two low-affinity sites and two sites that cannot bind ATP when high- and low-affinity sites are occupied8. ATP binding to the two high-affinity sites produces maximal function (for ...
(I) sites, thereby augmenting the catalytic activity of the Cu-BTC material. From the combined results of spectroscopy and theoretical calculations, it was concluded that coordinatively unsaturated Cu(I) centers mediated the dissociation of H2O2 into hydroxyl radicals, which reacted with additional ...