ATP hydrolysis energy explained through large-scale hybrid quantum/classical simulationsIn ATP hydrolysis, water is used to split apart adenosine triphosphate (ATP) to create adenosine diphosphate (ADP) to get energy. ATP hydrolysis energy (AHE) is then used in the activities of livi ...In ATP ...
The healthy growth and maintenance of a biological system depends on the precise spatial organization of molecules within the cell through the dissipation of energy. Reaction–diffusion mechanisms can facilitate this organization, as can directional cargo transport orchestrated by motor proteins, by relying...
Metabolic efficiency profoundly influences organismal fitness. Nonphotosynthetic organisms, from yeast to mammals, derive usable energy primarily through glycolysis and respiration. Although respiration is more energy efficient, some cells favor glycolys
The integrity of DNA is continuously challenged by metabolism-derived and environmental genotoxic agents that cause a variety of DNA lesions, including base alterations and breaks. DNA damage interferes with vital processes such as transcription and repl
Macromolecular assemblies that regulate chromatin structure using the energy of ATP hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of this family are encoded by 27 human genes and are usually associated with several other proteins that are stable, non-exch...
Joint pain during arthritis is produced by aberrant nociceptive circuits activated in the central nervous system [103], and ATP is released during tissue injury and critically modulates microglial activity [104]. Mousseau et al. found that joint injury is followed by an increase in nociceptive outp...
We have recently demonstrated that palmitoleic acid (16:1n7) increases lipolysis, glucose uptake and glucose utilization for energy production in white adipose cells. In the present study, we tested the hypothesis that palmitoleic acid modulates bioenergetic activity in white adipocytes. Methods For th...
ATP8A2 is a membrane-bound enzyme, a “flippase,” that utilizes the energy liberated by ATP hydrolysis to translocate (flip) the amino phospholipids phosphatidylserine (PS)2 and phosphatidylethanolamine (PE), but not phosphatidylcholine (PC), from the exoplasmic leaflet to the cytoplasmic leaflet...
The middle transition which can be assigned to the myosin rod has the largest activation energy. Very likely, this can be explained by the compact helical structure of the rod. The narrow line width at half height is the sign of the strong cooperative interaction between the molecules in rod...
reaction Γ’ = [ATP]/([ADP]∙[Pi]) influences the ATP synthesis rate. At chemical equilibrium, where no net ATP synthesis takes place the mass-action ratio is equal to the equilibrium constant K44. In equilibrium thermodynamics, the Gibbs free energy change is defined by the ...